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  4. MPP5 Antibody

MPP5 Antibody

  • 货号：
    CSB-PA014762GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8N3R9
  • 基因名：
  • 别名：
    FLJ12615 antibody; MAGUK p55 subfamily member 5 antibody; Membrane protein palmitoylated 5 antibody; MPP 5 antibody; MPP5 antibody; MPP5_HUMAN antibody; PALS 1 antibody; PALS1 antibody; Protein associated with Lin-7 antibody; Stardust (Drosophila) antibody; Stardust antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MPP5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells. Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface. Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity. Required during embryonic and postnatal retinal development. Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development. Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling. Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Plays a role in the T-cell receptor-mediated activation of NF-kappa-B. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton. Required for the normal polarized localization of the vesicular marker STX4. Required for the correct trafficking of the myelin proteins PMP22 and MAG. Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7.; (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity.
  • 基因功能参考文献：
    1. Removal of this side chain enhances the binding affinity by more than fivefold, suggesting that access of Crb to Pals1 may be regulated by intradomain contacts or by protein-protein interaction. PMID: 25760605
    2. The unique in-frame MPP5-FAM71D fusion product is important for proliferation of PC346C cells. PMID: 24488012
    3. the crystal structure of a 4-L27 domain-containing heterotrimer derived from the tripartite complex Patj/Pals1/Mals2 PMID: 22337881
    4. Crystals of tripartite complex 1 of L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS) diffracted to 2.05 A resolution PMID: 22102253
    5. Small irregularly shaped spots are detected throughout the Pals1-deficient retina of conditional knockdown mice by confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography. PMID: 22114289
    6. The cell polarity protein PALS1 is expressed in T lymphocytes and participates to the optimal activation of NF-kappaB following TCR stimulation. PMID: 21479189
    7. Data suggest that hijacking of PALS1 by SARS-CoV E plays a determinant role in the disruption of the lung epithelium in SARS patients. PMID: 20861307
    8. Polycystin-2 activity is controlled by transcriptional coactivator with PDZ binding motif and PALS1-associated tight junction protein PMID: 20833712
    9. Polarity protein associated with lin seven 1 (Pals1) plays an essential role in radical and longitudinal extension of the myelin sheath in peripheral nerves, likely involving membrane protein trafficking. PMID: 20237282
    10. Pals1 functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. PMID: 11927608
    11. the Crumbs3-Pals1 complex has a role in development of polarity in mammalian epithelial cells PMID: 12771187
    12. PDZ domain plasticity has a role in internal recognition in the Par-6-Pals1 complex PMID: 15475968

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  • 亚细胞定位：
    Golgi apparatus. Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Cell projection, axon. Perikaryon. Apical cell membrane.; Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus.
  • 蛋白家族：
    MAGUK family
  • 组织特异性：
    Expressed at the outer limiting membrane in the retina (at protein level). Expressed in T lymphocytes (at protein level). Expressed in the kidney (at protein level).
  • 数据库链接：

    HGNC: 18669

    OMIM: 606958

    KEGG: hsa:64398

    STRING: 9606.ENSP00000261681

    UniGene: Hs.652312