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MPRIP Antibody

  • 货号：
    CSB-PA014769GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6WCQ1
  • 基因名：
    MPRIP
  • 别名：
    9530046C02 antibody; AA536749 antibody; AI647711 antibody; C76423 antibody; KIAA0864 antibody; M-RIP antibody; MGC67316 antibody; mKIAA0864 antibody; Mprip antibody; MPRIP_HUMAN antibody; Myosin phosphatase Rho-interacting protein antibody; p116 Rho-interacting protein antibody; p116Rip antibody; Rho-interacting protein 3 antibody; Rhoip3 antibody; RIP3 antibody; RP23-180B18.4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MPRIP
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
  • 基因功能参考文献：
    1. The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury. PMID: 24901049
    2. Our data identify M-RIP as a crucial local regulator of the Rho-Rac balance during chemotaxis and antigen recognition. PMID: 22349701
    3. MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP and the inducible kinase NUAK2 PMID: 21242312
    4. p116Rip is an important regulatory component that controls the RhoA signaling pathway, thus regulating MLCP activity and myosin phosphorylation in cells PMID: 15545284
    5. M-RIP-dependent targeting of myosin phosphatase to stress fibers has an important role in regulating myosin light chain phosphorylation state and morphology in human vascular smooth muscle cells PMID: 16257966
    6. A functional analysis of JNK1 and M-RIP with RNA interference reveals a critical role for this cascade in the invasive behavior of cancer cells. PMID: 18636174

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin.
  • 数据库链接：

    HGNC: 30321

    OMIM: 612935

    KEGG: hsa:23164

    STRING: 9606.ENSP00000379156

    UniGene: Hs.462341