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MPS1 Antibody

  • 货号：
    CSB-PA346524XA01SVG
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes: MPS1 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 47 kDa
      Observed band size: 47 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) MPS1 Polyclonal antibody
  • Uniprot No.：
    P54199
  • 基因名：
    MPS1
  • 别名：
    Serine/threonine-protein kinase MPS1 (EC 2.7.12.2) (Monopolar spindle protein 1) (Regulatory cell proliferation kinase 1) MPS1 RPK1 YDL028C D2785
  • 宿主：
    Rabbit
  • 反应种属：
    Saccharomyces cerevisiae (Baker's yeast)
  • 免疫原：
    Recombinant Saccharomyces cerevisiae (Baker's yeast) MPS1 protein (40-289aa)
  • 免疫原种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Implicated in spindle pole body (SPD) duplication. Dual specificity kinase that can phosphorylate serine, threonine and tyrosine residues. Phosphorylates the SPC29 and SPC110 spindle pole body components.
  • 基因功能参考文献：
    1. An important role for Mps1 phosphorylation in the spindle assembly checkpoint activation, beyond the direct recruitment of Mad1 and Mad2. PMID: 27280788
    2. CCT271850 is a potent, selective and orally bioavailable MPS1 kinase inhibitor. On the basis of in vivo pharmacodynamic vs efficacy relationships, we predict that more than 80% inhibition of MPS1 activity for at least 24 h is required to achieve tumour stasis or regression by CCT271850. PMID: 28334731
    3. These findings highlight MPS1 as a rational therapeutic target for medulloblastoma PMID: 27633003
    4. Disrupting Mps1 before mitotic entry reduces chromosomal passenger complex (CPC) localization to the centromere. Mps1 plays a minimal role in maintaining CPC localization once cells are in mitosis. PMID: 25854549
    5. Mps1 kinase controls Cnn1 localization and activity at kinetochores through the cell cycle. PMID: 25716979
    6. Ipl1 released these improper connections, whereas Mps1 triggered the formation of new force-generating microtubule attachments. PMID: 23371552
    7. found that Sgo1 overexpression rescues defects caused by metaphase inactivation of Mps1 and that Mps1 is required for Sgo1 localization to the kinetochore PMID: 21389114
    8. Mps1 plays an important role in kinetochore attachment during mitotic spindle assembly and function. PMID: 15668173
    9. it was demonstrated that mutual inhibition between the anaphase-promoting complex (APC) and Mps1, an essential component of the checkpoint, leads to sustained inactivation of the spindle checkpoint PMID: 16825537
    10. Phosphorylation of Dam1 residues S218 and S221 by Mps1 is required for efficient coupling of kinetochores to microtubule plus ends. PMID: 16890524
    11. Mps1 promotes re-orientation of kinetochore-spindle pole connections and eliminates those that do not generate tension between sister kinetochores. PMID: 18060784
    12. Results suggest that a putative Mps1-dependent phosphorylation of Ndc80 is important for spindle assembly checkpoint activation at kinetochores. PMID: 19300438

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  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 数据库链接：

    KEGG: sce:YDL028C

    STRING: 4932.YDL028C