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MS4A6A Antibody

  • 货号：
    CSB-PA015018GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H2W1
  • 基因名：
    MS4A6A
  • 别名：
    MS4A6A; 4SPAN3; CD20L3; MS4A6; CDA01; MSTP090; Membrane-spanning 4-domains subfamily A member 6A; CD20 antigen-like 3; Four-span transmembrane protein 3
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human MS4A6A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in signal transduction as a component of a multimeric receptor complex.
  • 基因功能参考文献：
    1. Meta analysis validated the Alzheimer disease protective association for MS4A6A (rs610932) variants. PMID: 29504051
    2. rs610932 MS4A6A is not associated with late-onset Alzheimer's disease. PMID: 28477215
    3. these findings reveal that MS4A6A genotypes affect Alzheimer's disease specific brain structures PMID: 27244883
    4. Study found enrichment of epistasis in gonadotropin-releasing hormone signaling with risk single-nucleotide polymorphisms in APOE and MS4A6A. Results suggest that in addition to APOE, MS4A6A polymorphisms should be considered in hormone trials targeting gonadotropins. PMID: 27337227
    5. identified the significant associations of the GBA L444P mutation and DYRK1A rs8126696 T allele with the earlier age at onset (AAO) in Parkinson's disease (PD) patients, and the A allele at MS4A6A rs610932 with the delayed AAO of PD. PMID: 27085534
    6. Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy. PMID: 26923404
    7. high levels of MS4A6A contribute to altered turnover or production of cells with an anti-inflammatory neuroprotective phenotype in favor of cells with a damaging pro-inflammatory phenotype believed to contribute to AD pathology. PMID: 24064185
    8. data revealed the allele (T) of the rs3865444 polymorphism of the CD33 gene and the allele (C) of the rs610932 polymorphism of the MS4A6A gene may contribute to Alzheimer's disease risk in the Chinese Han population PMID: 22382309
    9. ABCA7 and the MS4A6A/MS4A4E gene cluster are new Alzheimer's disease susceptibility loci. PMID: 21460840

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    MS4A family
  • 组织特异性：
    Variable expression in some B-cell, myelomonocytic, and erythroleukemia cell lines.
  • 数据库链接：

    HGNC: 13375

    OMIM: 606548

    KEGG: hsa:64231

    STRING: 9606.ENSP00000315878

    UniGene: Hs.523702