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MSH5 Antibody

  • 货号：
    CSB-PA914618
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA914618(MSH5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA914618(MSH5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human testis tissue, U937 cells, Primary antibody: CSB-PA914618(MSH5 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

产品详情

  • Uniprot No.：
    O43196
  • 基因名：
  • 别名：
    DKFZp434C1615 antibody; G7 antibody; hMSH5 antibody; MGC2939 antibody; MSH 5 antibody; MSH5 antibody; MSH5_HUMAN antibody; mutS (E. coli) homolog 5 antibody; mutS homolog 5 antibody; mutS homolog 5 (E. coli) antibody; MutS protein homolog 5 antibody; MutSH5 antibody; NG23 antibody; OTTHUMP00000029187 antibody; OTTHUMP00000029188 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human MSH5
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis.
  • 基因功能参考文献：
    1. From sanger sequencing of MSH5 in 200 sporadic POI patients, we identified three heterozygous mutations . Considering the heterozygous p.D487Y carrier in the POI pedigree was fertile, the causality of the three heterozygous mutations in POI need more evidence PMID: 28175301
    2. our data point to the existence of a functional interplay between hMSH5 and FANCJ in double-strand break repair induced by replication stress. PMID: 26055704
    3. the roles of hMSH5 variants in the processes of DNA damage response and repair PMID: 24023853
    4. s show that MSH5 (MutSHomolog 5) is localized into the mitochondria of germ and somatic cells. PMID: 22917773
    5. Study has suggested a role for hMSH5 in the processing of cisplatin-induced DSBs, and silencing of hMSH5 may provide a new means to improve the therapeutic efficacy of cisplatin. PMID: 22401567
    6. The presence of the MSH5 85F allele marks the subgroup of DRB1*0102 haplotypes carrying susceptibility for selective IgA deficiency. MSH5 polymorphisms per se are not predisposing factors. PMID: 20542071
    7. hMSH5 possesses a CRM1-dependent nuclear export signal and a nuclear localization signal that participates to its nuclear targeting. PMID: 20185565
    8. There is an association of polymorphism C85T in MSH5 or C2531T in MLH3 with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 and MLH3 polymorphisms increased the risk of developing male infertility PMID: 19808033
    9. A review of the properties and functional roles of MSH5. PMID: 17127347
    10. These findings suggest that Msh4/5 heterodimers contribute to class switch recombination. PMID: 17409188
    11. Data show that MSH5 mutations may be one explanation for premature ovarian failure. PMID: 18166824
    12. Biochemical identification of the proteins with which it interacted showed that SMCY formed a distinct complex with MSH5, a critical meiosis-regulatory protein in the human testicular germ cell line, NEC8. PMID: 18459961
    13. this study implicates a role for hMSH5 in DNA damage response involving c-Abl and p73, and suggests that mutations impairing this process could significantly affect normal cellular responses to anti-cancer treatments. PMID: 19442657
    14. occurrence of an unusual TG 3' splice site in intron 6 PMID: 17672918

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  • 相关疾病：
    Premature ovarian failure 13 (POF13)
  • 蛋白家族：
    DNA mismatch repair MutS family
  • 组织特异性：
    Widely expressed, with high levels in testis and ovary, including granulosa cells. Also expressed in fetal ovary and adrenal gland.
  • 数据库链接：

    HGNC: 7328

    OMIM: 603382

    KEGG: hsa:4439

    STRING: 9606.ENSP00000364855

    UniGene: Hs.647011