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MSL2 Antibody

  • 货号：
    CSB-PA875722LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: U251 whole cell lysate
      All lanes: MSL2 antibody at 5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 63, 55 kDa
      Observed band size: 63 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MSL2 Polyclonal antibody
  • Uniprot No.：
    Q9HCI7
  • 基因名：
    MSL2
  • 别名：
    Male specific lethal 2 homolog (Drosophila) antibody; Male specific lethal 2 homolog 1 antibody; Male specific lethal 2 homolog antibody; Male specific lethal 2 like 1 antibody; Male-specific lethal 2 homolog antibody; Male-specific lethal 2-like 1 antibody; Male-specific lethal-2 homolog 1 antibody; MSL-2 antibody; MSL2 antibody; MSL2-like 1 antibody; MSL2_HUMAN antibody; MSL2L1 antibody; Ring finger protein 184 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase MSL2 protein (341-473AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MSL2 Antibody (CSB-PA875722LA01HU)，的标记方式是Non-conjugated。对于MSL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA875722LB01HU MSL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA875722LC01HU MSL2 Antibody, FITC conjugated
    Biotin CSB-PA875722LD01HU MSL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
  • 基因功能参考文献：
    1. HBx-elevated MSL2 modulates hepatitis B virus (HBV) cccDNA in hepatoma cells to promote hepatocarcinogenesis, forming a positive feedback loop of HBx/MSL2/cccDNA/HBV. PMID: 28608964
    2. Msl2 is a novel component of the vertebrate DNA damage response. PMID: 23874665
    3. MSL2, together with MSL1, has robust histone ubiquitylation activity that mainly targets nucleosomal H2B on lysine 34. PMID: 21726816
    4. A multisubunit human histone acetylase complex that contains homologs of the Drosophila MSL proteins MOF, MSL1 (hampin A), MSL2, and MSL3 was described. This complex is responsible for histone H4 lysine-16 acetylation of all cellular chromosomes. PMID: 16227571
  • 蛋白家族：
    MSL2 family
  • 数据库链接：

    HGNC: 25544

    OMIM: 614802

    KEGG: hsa:55167

    STRING: 9606.ENSP00000311827

    UniGene: Hs.18631