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MSR1 Antibody

  • 货号：
    CSB-PA281967
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA281967(MSR1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P21757
  • 基因名：
    MSR1
  • 别名：
    MSR1; SCARA1; Macrophage scavenger receptor types I and II; Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD antigen CD204
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human MSR1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.
  • 基因功能参考文献：
    1. The expression of CD204 in tumor-associated macrophages is associated with the aggressiveness of lung adenocarcinoma. PMID: 29850577
    2. Decreased expression by OxLDL in PMA-differentiated THP-1 macrophages. Increased expression in plaque vs. nonplaque lesion areas in human carotid endarterectomy specimens (correlated with CD36 expression). PMID: 18827892
    3. Cytokine abnormality induced by SRA(+) cells playS an role in tissue injury, and platelet emboli or contraction band necrosis might have been the leading cause of death in our SUDI cases. PMID: 21790861
    4. TGM2 has a role in macrophage differentiation via mechanisms involving CD14 and SR-AI receptors. PMID: 27378395
    5. study demonstrates the elevated SR-A expression on cell surface contributes to increased susceptibility to Adenovirus serotype 5 (Ad5) infection into CD14+ monocytes; SR-A-mediated Ad5 entry, TLR3 signaling activation and acLDL accumulation in monocytes/ macrophages synergistically trigger the inflammatory responses and innate immunity against Ad5 infection PMID: 29680370
    6. SR-A1 expression in 136 human gliomas was positively correlated with tumor grade (P<0.01), but not prognosis or tumor recurrence PMID: 27367025
    7. The results reveal marked differences between afferent and efferent ymphatic endothelial cells and identify molecules on lymphatic vessels. Further characterizations of Siglec-1 (CD169) and macrophage scavenger receptor 1 (MSR1/CD204), show that they are discriminatively expressed on lymphatic endothelium of the subcapsular sinus but not on lymphatic vasculature of the lymphatic sinus PMID: 27601677
    8. High density of CD204(+) tumor-associated macrophages was associated with the aggressive behavior and worse survival of gastric cancer. Low density of CD204(+) TAMs was associated with infection of EBV, which may explain the favorable outcome of EBV-associated gastric carcinoma. PMID: 27342912
    9. SR-A1 suppresses lung cancer metastasis by downregulating SAA1 production in tumor-associated macrophages (TAM). PMID: 28202524
    10. PTX2 was identified PTX2 as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages. PMID: 28213380
    11. we found that higher percentages of circulating CD14+CD204+, CD14+CD163+CD204+ M2-like monocytes were significantly associated with TNM stage, lymph node metastasis, and histological differentiation. PMID: 28639912
    12. Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO. PMID: 26892079
    13. Findings suggest that CD204+ Mphis might play detrimental protumoral roles and represent the predominant Mphi phenotype in human bladder cancer. PMID: 26001293
    14. The P275A Polymorphism in the Macrophage Scavenger Receptor 1 Gene is not associated with Prostate Cancer Risk. PMID: 26225686
    15. Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pathway in esophageal squamous cell carcinoma PMID: 25620088
    16. miR-29a promotes scavenger receptor A expression by targeting QKI during monocyte-macrophage differentiation. PMID: 26056009
    17. Heptapeptide XD4 activates the class A scavenger receptor (SR-A) on the glia by increasing the binding of Abeta to SR-A, thereby promoting glial phagocytosis of Abeta oligomer in microglia. PMID: 24718459
    18. The truncating variant Arg293X in the gene encoding SRA-I/II was associated with reduced lung function and with increased risk of COPD among men, as well as among alpha1-antitrypsin MZ and superoxide dismutase-3 E1I1 heterozygotes. PMID: 25186548
    19. monomeric collagen type I via CD204 induces phospho-Akt expression shifting alveolar macrophages to the profibrotic M2 type. Innate immune responses induced by collagen monomers might perpetuate pulmonary fibrosis. PMID: 24278429
    20. High CD204 expression is an independent predictor for both overall and disease-free survival in pancreatic ductal adenocarcinoma. PMID: 24839953
    21. High CD204 expression is associated with metastasis and recurrence in non-small-cell lung cancer. PMID: 24419414
    22. There was a significant negative correlation between the number of CD163(+), CD204(+) or CD206(+) alveolar macrophages. PMID: 24498098
    23. rs6966 (3' UTR of PPP1R13L, chr 19q13.32, P = 4.55 x 10(-9)) and rs414580 (intron 2 of MSR1, chr 8p22, P = 6.09 x 10(-8)) were significantly associated with ALL. PMID: 24604828
    24. Our data suggest that inefficient folding of SR-AI variants with truncated SRCR domain was recognized by the endoplasmic reticulum associated degradation which leads to the immature N- glycosylation and intracellular retention PMID: 23915271
    25. CD204 is a useful marker for TAMs contributing to the angiogenesis. PMID: 23648122
    26. MSR1 to be a critical component of a TLR3-mediated pattern recognition receptor response that exerts an antiviral state in both infected and uninfected hepatocytes, thereby limiting the impact of HCV proteins that disrupt IFN signaling in infected cells PMID: 23717201
    27. In this review, we showed that SR-A and MARCO trigger intracellular signaling, modulating pro-inflammatory and microbicidal activities of macrophages. PMID: 22470185
    28. This review demonstrated that class A SR and MARCO are major pattern recognition receptors mediating opsonin-independent phagocytosis. PMID: 22470186
    29. Data suggest that pulmonary metastasis is corrected with levels of Geminin, cleaved caspase-3, CD44, E-cadherin, epidermal growth factor receptor, and CD204 in cancer cells within permeated lymphatic vessels. PMID: 22429811
    30. The results of this study found that SR-AI/II was highly expressed on the surface of foamy macrophages in MS lesions. PMID: 23334594
    31. We identified in a Chinese population a functional polymorphism in SR-A linked to lung cancer risk. In vivo and in vitro studies demonstrated that SR-A may negatively modulate lung cancer growth and angiogenesis by regulating MMP9 production. PMID: 22878280
    32. Through regulating PI3K/Akt and ERK activity, PKCdelta affects SR-A and CD36 expression and foam cell formation. PMID: 22687273
    33. In patients with symptoms of acute coronary syndrome the amount of CD36 and MSR1 mRNA in circulating monocytes, as well as the density of both receptors on the cells surface was significantly higher. PMID: 22763563
    34. Identified a novel peptide antagonist selective for SR-AI which could be a valuable tool in SR-AI targeted imaging of atherosclerotic lesions. PMID: 22282357
    35. Msr1 suppresses leukemia stem cells and chronic myeloid leukemia development. PMID: 21596859
    36. Interleukin 10 abrogated the oxidized low density lipoprotein-induced SR-A mRNA expression by 50.2+/-3.9% and its protein by 45.6+/-1.9%. PMID: 21658363
    37. Pattern recognition scavenger receptor CD204 attenuates Toll-like receptor 4-induced NF-kappaB activation by directly inhibiting ubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6. PMID: 21460221
    38. novel property of SR-AI as a complement receptor for iC3b-opsonized bacteria that can elicit cell signaling PMID: 21203986
    39. IFNalpha priming up-regulated the expression of SR-A in human monocyte/macrophages, leading to increased lipid uptake and foam cell formation. PMID: 21280004
    40. Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma. PMID: 20802348
    41. human protein S can inhibit the expression and activity of SR-A through Mer RTK in macrophages, suggesting that human protein S is a modulator for macrophage functions in uptaking of modified lipoproteins PMID: 18922854
    42. SRA-1 is an endocytic receptor for hepatitis C virus non-structural protein 3 in dendritic cells. PMID: 20338659
    43. Decreased infiltration of macrophage scavenger receptor-positive cells in initial negative biopsy specimens is correlated with positive repeat biopsies of the prostate. PMID: 20384632
    44. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    45. CD36 and SR-A play an important role in platelet-induced foam cell formation from CD34(+) progenitor cells PMID: 20414830
    46. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    47. The MSR1 association with COPD susceptibility, COPD-related measures of lung function, and abnormalities of macrophage function may account for significant COPD morbidity. PMID: 20081102
    48. Our findings corroborate the involvement of ELAC2, MSR1, and RNASEL in the etiology of prostate cancer even in individuals without a family history. PMID: 20086112
    49. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) PMID: 20086112
    50. Macrophage SR-A is found to recognize exchangeable apolipoproteins (Apo)A-I and ApoE in both lipid-free and lipid-associated form, suggesting the shared amphipathic alpha-helix as a potential recognition motif. PMID: 19911804

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  • 相关疾病：
    Prostate cancer (PC); Barrett esophagus (BE)
  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. Isoform I and isoform II are expressed in the liver, placenta and brain.
  • 数据库链接：

    HGNC: 7376

    OMIM: 153622

    KEGG: hsa:4481

    STRING: 9606.ENSP00000262101

    UniGene: Hs.147635