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MSRB1 Antibody

  • 货号：
    CSB-PA882163LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA882163LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA882163LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA882163LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MSRB1 Polyclonal antibody
  • Uniprot No.：
    Q9NZV6
  • 基因名：
    MSRB1
  • 别名：
    Annexin A2 like antibody; EC 1 8 4 antibody; HSPC 270 antibody; HSPC270 antibody; Methionine R sulfoxide reductase antibody; Methionine R sulfoxide reductase B1 antibody; Methionine sulfoxide reductase antibody; Methionine-R-sulfoxide reductase B1 antibody; MGC3344 antibody; MSRB 1 antibody; MsrB1 antibody; MSRB1_HUMAN antibody; OTTHUMP00000159418 antibody; Sel X antibody; Selenoprotein R antibody; Selenoprotein X 1 antibody; Selenoprotein X antibody; Selenoprotein X1 antibody; SELR antibody; SelX antibody; SEPX 1 antibody; sepx1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Methionine-R-sulfoxide reductase B1 protein (1-116AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MSRB1 Antibody (CSB-PA882163LA01HU)，的标记方式是Non-conjugated。对于MSRB1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA882163LB01HU MSRB1 Antibody, HRP conjugated ELISA
    FITC CSB-PA882163LC01HU MSRB1 Antibody, FITC conjugated
    Biotin CSB-PA882163LD01HU MSRB1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
  • 基因功能参考文献：
    1. In vivo, MsrB1 shRNAi can inhibit lung metastasis in metastasis model. In conclusion, MsrB1 regulates proliferation and invasion of u2os cells by affecting MAPK pathway and EMT, and MsrB1 gene may be a novel therapeutic target against tumors. PMID: 29395081
    2. FRET and co-IP assays demonstrated that Clu interacted with beta-amyloid peptide, a pathological protein of AD, which suggested a potential effect of SelR and Abeta with the aid of Clu. The interaction between SelR and Clu provides a novel avenue for further study on the mechanism of SelR in AD prevention. PMID: 23805218
    3. MsrB1 protected human lens epithelial cells against the peroxynitrite-induced F-actin disruption. PMID: 24342607
    4. findings suggested that SelX played important roles in protecting LO2 cells against oxidative damage and reducing H2O2-induced apoptosis in liver cells. PMID: 26899321
    5. Selenoprotein R Protects Human Lens Epithelial Cells against D-Galactose-Induced Apoptosis by Regulating Oxidative Stress and Endoplasmic Reticulum Stress PMID: 26875981
    6. Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress. PMID: 23988788
    7. MsrB1 protected human lens epithelial cells against the peroxynitrite-induced F-actin disruption PMID: 24342607
    8. MsrB1 plays important roles in protecting HLE cell mitochondria against oxidative damage and inhibits oxidative stress-induced apoptosis in diabetic cataracts by scavenging ROS. PMID: 23270945
    9. The results demonstrate that in human lens epithelial cells MsrB1 may play important roles in regulating redox balance and mitigating endoplasmic reticulum stress. PMID: 22713178
    10. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 21048031
    11. The neutrophils expressed the highest activity Msrs. Msrs are important as antioxidant/repair systems for neutrophils, cells with enormous capacity for the generation of reactive oxidants and hence, susceptible to oxidative damage. PMID: 17938273
    12. Strong candidate gene for schizophrenia; upregulated in lymphoblastoid cells of monozygotic twins. PMID: 18081029
    13. The studies in mouse show that MsrB is a selenoprotein that exhibits high specificity for reduction of the R forms of free and protein-bound methionine sulfoxide. PMID: 11779133

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    MsrB Met sulfoxide reductase family
  • 数据库链接：

    HGNC: 14133

    OMIM: 606216

    KEGG: hsa:51734

    STRING: 9606.ENSP00000355084

    UniGene: Hs.655346