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MSRB2 Antibody

  • 货号：
    CSB-PA896505DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: MSRB2antibody at 5.58μg/ml + Mouse heart tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 20 kDa
      Observed band size: 20 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA896505DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MSRB2 Polyclonal antibody
  • Uniprot No.：
    Q9Y3D2
  • 基因名：
    MSRB2
  • 别名：
    CBS 1 antibody; CBS1 antibody; CGI 131 antibody; Methionine sulfoxide reductase B2 antibody; Methionine-R-sulfoxide reductase B2 antibody; MGC26104 antibody; mitochondrial antibody; MSRB 2 antibody; MSRB antibody; Msrb2 antibody; MSRB2_HUMAN antibody; PILB antibody; Pilin like transcription factor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Methionine-R-sulfoxide reductase B2, mitochondrial protein (10-182AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.
  • 基因功能参考文献：
    1. this study we have identified, for the first time, compounds structurally related to the natural products fusaricidins that markedly activate recombinant bovine and human MsrA and human MsrB. PMID: 26718410
    2. Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress. PMID: 23988788
    3. the mitochondrial methionine-R-sulfoxide reductase B2 (MSRB2) is a specific interaction partner of LG72. PMID: 25078755
    4. Data show that glutaredoxin acts as a reductant for methionine sulfoxide reductases A and B (MsrA and MsrB) with or without resolving cysteine. PMID: 22634633
    5. CBS1, a methionine sulfoxide reductase of type B, is most abundant in muscle tissues, especially in the heart and thereby shows an expression pattern different to the human methionine sulfoxide reductase A PMID: 12220640
    6. MSRB is down-regulated during cell aging. PMID: 14759519
    7. hMSRB2 expression was weak in brain, but strong in heart, skeletal muscle, and smooth muscle-containing organs (digestive system, bladder), lung and aorta, while hMSRB1 displayed a higher expression in liver and kidney PMID: 14980072
    8. showed the expression and function of both sulfoxide reductases together with thioredoxin reductase in the cytosol as well as in the nucleus of epidermal melanocytes which are especially sensitive to reactive oxygen PMID: 16480945
    9. Methionine sulfoxide reductases A and B are seriously affected by hydrogen peroxide accumulation in acute vitiligo. PMID: 17943184
    10. upon oxidative stress, the overexpression of methionine sulfoxide reductase B2 leads to the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role PMID: 18424444
    11. almost absent catalase and methionine sulfoxide reductase A and B protein expression in human gray/white scalp hair shafts in association with a functional loss of methionine sulfoxide repair in the entire gray hair follicle PMID: 19237503
    12. MSR enzymes are differentially expressed in human skin. PMID: 19542914

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    MsrB Met sulfoxide reductase family
  • 组织特异性：
    Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate.
  • 数据库链接：

    HGNC: 17061

    OMIM: 613782

    KEGG: hsa:22921

    STRING: 9606.ENSP00000365693

    UniGene: Hs.461420