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MT1F Antibody

  • 货号：
    CSB-PA17409A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MT1F Polyclonal antibody
  • Uniprot No.：
    P04733
  • 基因名：
    MT1F
  • 别名：
    MT1F antibody; PRO0376 antibody; Metallothionein-1F antibody; MT-1F antibody; Metallothionein-IF antibody; MT-IF antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Metallothionein-1F protein (1-61AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MT1F Antibody (CSB-PA17409A0Rb)，的标记方式是Non-conjugated。对于MT1F Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA17409B0Rb MT1F Antibody, HRP conjugated ELISA
    FITC CSB-PA17409C0Rb MT1F Antibody, FITC conjugated
    Biotin CSB-PA17409D0Rb MT1F Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
  • 基因功能参考文献：
    1. we found that metallothionein expression induced by Cd occurred much later, with the expression seen at least 12h or more after the Nrf2-dependent immediate responses were almost completed. PMID: 24440467
    2. Metallothionein may have a role in the control of apoptosis in pleomorphic adenoma. PMID: 23332881
    3. Aortic protection in diabetes by zinc supplementation is associated with upregulation of both metallothionein and Nrf2 expression. PMID: 23536959
    4. findings show 5 MT isoforms were overexpressed in non-small cell lung cancer and overexpression of MT-1F and MT-2A predicted poor outcome; both isoforms may be involved in progression of this cancer type; upregulated MT-1F expression associated with larger primary tumor size and higher grade of malignanacy PMID: 23064051
    5. MT1F is a putative tumor suppressor gene in colon carcinogenesis that is downregulated mainly by loss of heterozygosity in colon cancer tissue PMID: 22426038
    6. This study identifies for the first time the relevant metallothionein isoforms for colorectal cancer progression. PMID: 21820154
    7. Studies provide the mechanistic properties of metal binding for metallothionein metallation. PMID: 21409206
    8. MT-1 rs8052394 A allele is associated with oral squamous cell carcinoma. PMID: 21128001
    9. In the liver cancer tissue, MT1F shows down-regulated expression that supports the inhibited function of MT1F in cancer growth PMID: 15369632
    10. Knockdown of MT1F gene increased particular matter(2.5)-induced H2O2 release in alveolar macrophages. PMID: 19251948

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  • 蛋白家族：
    Metallothionein superfamily, Type 1 family
  • 数据库链接：

    HGNC: 7398

    OMIM: 156352

    KEGG: hsa:4494

    STRING: 9606.ENSP00000334872

    UniGene: Hs.513626