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MTIF3 Antibody

  • 货号：
    CSB-PA008192
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEC cells using IF3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9H2K0
  • 基因名：
    MTIF3
  • 别名：
    DC38 antibody; IF 3 antibody; IF 3Mt antibody; IF-3(Mt) antibody; IF-3Mt antibody; IF3 antibody; IF3(mt) antibody; IF3M_HUMAN antibody; IF3mt antibody; mitochondrial antibody; Mt antibody; MTIF3 antibody; Translation initiation factor IF 3; mitochondrial precursor antibody; Translation initiation factor IF-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human IF3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
  • 基因功能参考文献：
    1. genetic association studies in cohorts of prediabetic patients at multiple sites: Data suggest that an SNP in MTIF3 (rs1885988) is associated with greater weight loss following lifestyle intervention in overweight/obese subjects with prediabetes. PMID: 26253612
    2. single nucleotide polymorphisms rs4771122 of MTIF3 was the variant most significantly associated with long-term weight loss after surgery. PMID: 26337695
    3. Changes in function or expression of MTIF3 indicates mitochondrial dysfunction and contributes to the risk of Parkinson's disease. PMID: 20887776
    4. the c.798C>T polymorphism of the MTIF3 gene showed allelic association with Parkinson's disease PMID: 17267121
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    IF-3 family
  • 数据库链接：

    HGNC: 29788

    KEGG: hsa:219402

    STRING: 9606.ENSP00000370508

    UniGene: Hs.534582