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  4. MUC13 Antibody

MUC13 Antibody

  • 货号：
    CSB-PA003335
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using Mucin 13 Polyclonal Antibody
    • Western Blot analysis of L929 cells using Mucin 13 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9H3R2
  • 基因名：
  • 别名：
    Down-regulated in colon cancer 1 antibody; DRCC1 antibody; FLJ20063 antibody; MUC 13 antibody; MUC-13 antibody; Muc13 antibody; MUC13 Down regulated in colon cancer 1 antibody; MUC13_HUMAN antibody; Mucin 13; cell surface associated antibody; Mucin-13 antibody; PRO20221 antibody; RECC antibody; UNQ6194 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Mucin 13.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.
  • 基因功能参考文献：
    1. The results suggest that MUC13 overexpression and loss of expression of AGR2 may predict the progression of Intraductal papillary mucinous neoplasm and an unfavorable prognosis in patients with Intraductal papillary mucinous neoplasm PMID: 29650332
    2. our study first demonstrated that USF1 could activate the transcription of MUC13, thereby enhancing the proliferation and self-renewal of glioblastoma stem cells PMID: 29441861
    3. MUC13 high expression is a novel independent adverse prognostic factor of clinical outcome in non-metastatic clear cell renal cell carcinoma patients after surgery. PMID: 27911274
    4. Luciferase assays and western blot confirmed MUC13 as a target gene of miR1323p. PMID: 28339011
    5. Results from this study demonstrate that MUC13 Functionally interacts and activates HER2 at p1248 in PDAC cells, leading to stimulation of HER2 signaling cascade, including ERK1/2, FAK, AKT and PAK1 as well as regulation of the growth, cytoskeleton remodeling and motility, invasion of PDAC cells-all collectively contributing to PDAC progression. PMID: 27321183
    6. High MUC13 expression is associated with renal cell carcinoma and drug resistance. PMID: 28205224
    7. A combination of MUC13/MUC20 expression was a potential prognostic marker for patients with ESCC, who received neoadjuvant chemotherapy followed by surgery. PMID: 26323930
    8. Results show that pancreatic ductal adenocarcinoma cells express higher levels of MUC13 and is associated with poor outcome when expressed at low level. PMID: 25672256
    9. Based on nasopharyngeal MUC13 gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants. PMID: 25261323
    10. These results suggest miR-145 as a novel regulator of MUC13 in pancreatic cancer. PMID: 25277192
    11. Overexpression of MUC13 increased cell growth, colony formation, cell migration, and invasion in colon cancer cells. PMID: 24097071
    12. MUC13 is epigenetically regulated in ovarian cancer. PMID: 25048476
    13. Overexpression of MUC13 is associated with pancreatic neuroendocrine tumors. PMID: 24114056
    14. GALNT14 may contribute to ovarian carcinogenesis through aberrant glycosylation of MUC13. PMID: 23708057
    15. Metastatic colon cancer and liver metastasis tissue samples demonstrated significantly (p<0.05) higher cytoplasmic and nuclear MUC13 expression compared with non-metastatic colon cancer and adjacent normal colon samples. PMID: 22914648
    16. MUC13 overexpression caused a significant increase in cell motility, invasion, proliferation, and anchorage-dependent or -independent clonogenicity while decreasing cell-cell and cell-substratum adhesion in pancreatic cancer. PMID: 22027689
    17. The various functional domains of MUC13 may confer oncogenic potential to MUC13 PMID: 21450906
    18. MUC13 is a good differentiation marker for gastrointestinal mucosa PMID: 15904467
    19. Aberrant intestinal expression and allelic variant MUC13 is associated with inflammatory bowel disease. PMID: 17058067
    20. Reflux laryngitis is associated with down-regulation of mucin gene expression. PMID: 18834073
    21. Findings show the aberrant expression of MUC13 in ovarian cancer and that its expression alters the cellular characteristics of SKOV-3 cells. This implies a significant role of MUC13 in ovarian cancer. PMID: 19176398

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Apical cell membrane. Secreted. Note=Also exists as a soluble form.
  • 组织特异性：
    Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.
  • 数据库链接：

    HGNC: 7511

    OMIM: 612181

    KEGG: hsa:56667

    STRING: 9606.ENSP00000312235

    UniGene: Hs.5940