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MUC3A Antibody

  • 货号：
    CSB-PA130507
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA130507(MUC3A Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA130507(MUC3A Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q02505
  • 基因名：
    MUC3A
  • 别名：
    MUC3A antibody; MUC3 antibody; Mucin-3A antibody; MUC-3A antibody; Intestinal mucin-3A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human MUC3A
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.
  • 基因功能参考文献：
    1. MUC3A may have a role in poor prognosis in localized clear-cell renal cell carcinoma PMID: 27374181
    2. DNA hypomethylation in the 5'-flanking region of the MUC3A gene plays an important role in MUC3A expression in carcinomas of various organs. PMID: 20510874
    3. has highly conserved amino and carboxyl termini, suggesting a recent duplication of the entire ancestral gene PMID: 12958310
    4. MUC3 is overexpressed in renal clear cell carcinoma, and the MUC3 expression ratio is greater in nuclear grade 3 than in grades 1 and 2 (low grades) tumor. These findings suggest the implication of MUC3 in renal carcinogenesis. PMID: 14550470
    5. up-regulated MUC expression by synovial tissue cells and suggest a novel role of MUC3 and MUC5AC in the pathogenesis of arthritis PMID: 18163520
    6. We report the colonic adhesion mechanism of Lactobaillus plantarums LA318 is in part due to GAPDH binding to human ABO-type blood group antigens expressed on human colonic mucin (HCM). [HCM] PMID: 18790050
    7. Data show that the diagnostic sensitivity for mucin was 60%, and the specificity for mucin was 100%. PMID: 19365834
    8. Data show that special stains for mucin did not distinguish pseudocysts from neoplastic mucinous cysts. PMID: 19365837

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  • 亚细胞定位：
    [Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.
  • 组织特异性：
    Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.
  • 数据库链接：

    HGNC: 7513

    OMIM: 158371

    KEGG: hsa:4584

    STRING: 9606.ENSP00000324834

    UniGene: Hs.703577