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MUC5B Antibody

  • 货号：
    CSB-PA875718LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA875718LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-PA875718LA01HU diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MUC5B Polyclonal antibody
  • Uniprot No.：
    Q9HC84
  • 基因名：
  • 别名：
    Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin), MUC5B, MUC5
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Mucin-5B protein (3929-4106aa)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MUC5B Antibody (CSB-PA875718LA01HU)，的标记方式是Non-conjugated。对于MUC5B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA875718LB01HU MUC5B Antibody, HRP conjugated ELISA
    FITC CSB-PA875718LC01HU MUC5B Antibody, FITC conjugated
    Biotin CSB-PA875718LD01HU MUC5B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.
  • 基因功能参考文献：
    1. the combination of intracellular packing of the MUC5B mucin and the submucosal gland morphology creates an efficient machine for producing linear mucin bundles. PMID: 29440393
    2. resistin induced MUC5AC and MUC5B expression via activation of different signaling pathways in human airway epithelial cells. PMID: 29604272
    3. Genetic variations in the MUC5B gene can influence dental caries. PMID: 28944591
    4. The expression of MUC5B mRNA increased with increases in NH concentration, and was significantly higher compared to that in untreated cells. H. pylori may affect the expression of MUC5AC, MUC2, MUC5B, and MUC6 in AGS cells via CagA and/or NH, but not E-cadherin. PMID: 29869461
    5. MUC5B was identified as PRP-1 receptor in human chondrosarcoma JJ012 cell line using Ligand-receptor capture technology. PMID: 29138803
    6. The MUC5B promoter polymorphism is strongly associated with interstitial lung abnormalities and specific radiologic subtypes of ILA, with varying degrees of heterogeneity in the underlying populations PMID: 28893869
    7. The associations between MUC5B rs35705950 and short telomere length with extent of fibrosis, histopathological features of usual interstitial pneumonia, and reduced survival in patients with chronic hypersensitivity pneumonitis suggest shared pathobiology with IPF, and might help to stratify risk. PMID: 28648751
    8. High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells PMID: 29286856
    9. IL-33 induced MUC5AC mRNA and MUC5AC protein, and also goblet cell hyperplasia at air liquid interface culture in human nasal epithelial cells. In addition to that, IL-33 induced MUC5B and FOXA3, and reduces FOXJmRNA. PMID: 27776277
    10. MUC5B has physiologic functions in the mucus gel that ensure normal mucus clearance. PMID: 27845589
    11. Down-regulation of MUC5B profoundly alters proliferation, migration and invasion of gastrointestinal cancer cells. PMID: 28972071
    12. Mucins and AQP5 gene expression were significantly higher in patients with OME relative to controls. A 2-fold increase in MUC5B correlated with increased hearing loss (air-bone gap: 7.45 dB [95% CI, 2.65-12.24 dB]; sound field: 6.66 dB [95% CI, 6.63-6.69 dB]), effusion viscosity (2.75 mL/mg; 95% CI, 0.89-4.62 mL/mg), middle ear epithelial thickness (3.5 mum; 95% CI, 1.96-5.13 mum), and neutrophil infiltration (odds rat... PMID: 28594978
    13. This study identified rare and common variants in the MUC5B gene that are associated with type 2 diabetes in Han Chinese. These findings suggest that dysregulated MUC5B expression may be involved in the pathogenesis of type 2 diabetes. PMID: 28346466
    14. a critical regulatory domain that contains the MUC5B promoter variant and has a highly conserved forkhead box protein A2 (FOXA2) binding motif, is identified. PMID: 28272906
    15. There is no evidence of major proteolytic processing of D-domains during the production of the mature secreted polymeric mucin in normal and cystic fibrosis primary bronchial epithelial cells. PMID: 26993521
    16. Different rs35705950 SNP alleles are associated with different CT imaging phenotypes of pulmonary fibrosis. PMID: 26836909
    17. MUC5B was significantly more often detected in middle ear effusion fluid relative to MUC5AC. MUC5B presence was statistically associated with mucoid effusions relative to serous effusions. PMID: 27729120
    18. Results collectively indicate unique links between dual-specificity phosphatase 28 (DUSP28) and mucins MUC5B/MUC16 and their roles in pancreatic cancer. PMID: 27230679
    19. Study provides evidence showing that MUC5B expression in cancer cells contributes to certain tumorigenic properties of breast cancer cells, such as cell growth, adhesion, clonogenic ability and drug chemo-resistance. PMID: 26984395
    20. this study shows that histamine activated the NF-kappaB pathway, contributing to MUC5B overproduction and secretion in nasal epithelial cells PMID: 26574733
    21. This study showed that MUC5B minor allele predisposes to poradic idiopathic pulmonary fi brosis (spIPF), familial interstitial pneumonia (FIP) and idiopathic non-speci fi c interstitial pneumonia. In spIPF, survival is not in fl uenced by MUC5B alleles. In FIP, MUC5B minor allele predicts better survival. PMID: 26699835
    22. MUC5B may play a role in the development of pediatric fibrotic lung disease in patients with Surfactant Protein C mutations PMID: 25858779
    23. the MUC5B polymorphism rs35705950 is associated with increased risk of idiopathic pulmonary fibrosis susceptibility, severity, and the decreased overall survival. PMID: 26823827
    24. The MUC5B promoter polymorphism is the strongest and the most replicated genetic risk factor for Idiopathic pulmonary fibrosis. It is involved in disease pathogenesis through an increase in MUC5B expression in terminal bronchi and honeycombed cysts. PMID: 26595739
    25. We propose a mechanism whereby MUC5B decreases surface tension lowering capacity of alveolar surfactant at areas with maximal mechanical stress PMID: 26539479
    26. These results suggest that MUC5B production can be regulated by ECM components and that MUC5B is upregulated by fibronectin and laminin via the integrin, ERK, and NF-kappaB dependent pathway. PMID: 26057585
    27. MUC5B promoter genotype was not associated with high attenuation areas on lung computed tomography. PMID: 26514822
    28. Overexpression of MUC5B has been described in idiopathic pulmonary fibrosis lungs. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201507-1322LE#.V2WAGNLrtNs PMID: 26871672
    29. The variant allele of a common MUC5B promoter variant, rs35705950, is significantly associated with both familial and sporadic idiopathic pulmonary fibrosis. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201509-1872LE#.V2WBpNLrtNs PMID: 26871673
    30. Mucin 5B promoter polymorphism is associated with the risk for interstitial lung diseases mainly in older male Chinese subjects PMID: 25121989
    31. MUC5B is a novel prognostic biomarker for patients with non-small cell lung cancer (NSCLC)carrying EGFR mutations but not for patients with NSCLC carrying wild-type EGFR PMID: 26224019
    32. MUC5B has recently been shown to be associated with idiopathic pulmonary fibrosis susceptibility and survival. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201505-1010OC#.VwqiYdLrvyA PMID: 26331942
    33. strong association between the MUC5B promoter rs35705950 minor T allele and idiopathic pulmonary fibrosis susceptibility particularly evident in the Caucasian population, milder but still significant in the Asian population [meta-analysis] PMID: 26512610
    34. this is the first study to successfully validate the association between rs35705950 and IPF in a Japanese ethnicity. PMID: 25581455
    35. Increased expression of MUC5B was associated with bacterial biofilm formation in chronic rhinosinusitis patients. PMID: 25638393
    36. MUC5B polymorphism confers susceptibility to idiopathic pulmonary fibrosis in Europeans and Asians--{review} PMID: 25926289
    37. Both compounds down regulated mucin 5 subtype B, and peptidoglycan recognition protein 1 in vaginal tissue PMID: 25333937
    38. the combination of MUC5B and TTF-1 expression is useful for discriminating adenocarcinomas from squamous cell carcinomas, yielding prognostic significance in patients with lung adenocarcinoma. PMID: 25733373
    39. An increase of MUC5B abundance found in the sinus secretions of pediatric patients with chronic rhinosinusitis. PMID: 25420179
    40. The T allele at rs35705950 of the MUC5B gene is associated with usual interstitial pneumonitis PMID: 25317858
    41. The expression of a subset of mucins (MUC2, MUC6, MUC5B) was also correlated with sialyl-Tn expression in LS174T cells. PMID: 24840470
    42. These results show for the first time that Staphylococcus enterotoxin A induces MUC5B expression via TLR2, ERK1/2, and p38 MAPK signaling pathway in human airway epithelial cells. PMID: 24717875
    43. The MUC5B rs2672794 CC genotype was associated with a significantly increased risk of coal workers' pneumoconiosis, compared with the TT genotype. PMID: 24924948
    44. Adolescents with very high intensity of dental caries disease had increased levels of MUC1 and MUC5B. PMID: 24441930
    45. Sputum is not inert and degradation reduces apparent mucin concentrations and sputum elasticity. PMID: 24332705
    46. These results suggest that visfatin induces MUC8 and MUC5B expression through p38 MAPK/ROS/NF-kappaB signaling pathway in human airway epithelial cells. PMID: 24885580
    47. TSLP induces MUC5B expression via the ERK1/2 and p38 MAPK signaling pathway in human airway epithelial cells. PMID: 24792379
    48. we report the expression pattern of MUC2, MUC5AC, MUC5B, and MUC6 in a large series of colorectal carcinomas PMID: 23807779
    49. This study suggests that although both MUC5B and TERT polymorphisms confer independent risks for interstitial lung disease (ILD), MUC5B rs35705950 may, in particular, contribute differentially to idiopathic pulmonary fibrosis and other ILD entities. PMID: 24434656
    50. One SNP in the MUC5B gene having association with chronic otitis media with effusion in study population. PMID: 23929584

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  • 相关疾病：
    Pulmonary fibrosis, idiopathic (IPF)
  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas.
  • 数据库链接：

    HGNC: 7516

    OMIM: 178500

    KEGG: hsa:727897

    STRING: 9606.ENSP00000436812

    UniGene: Hs.523395