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MYL12B Antibody

  • 货号：
    CSB-PA015308GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O14950
  • 基因名：
  • 别名：
    ML12B_HUMAN antibody; MLC 2A antibody; MLC-2 antibody; MLC-2a antibody; MLC-B antibody; MLC20 antibody; MRLC2 antibody; MYL12B antibody; MYLC2B antibody; Myosin light chain 12B regulatory antibody; Myosin regulatory light chain 12B antibody; myosin regulatory light chain 2 antibody; Myosin regulatory light chain 2-B antibody; myosin regulatory light chain 2-B; smooth muscle isoform antibody; Myosin regulatory light chain 20 kDa antibody; Myosin regulatory light chain MRLC2 antibody; myosin; light chain 12B; regulatory antibody; OTTHUMP00000162244 antibody; OTTHUMP00000165806 antibody; OTTHUMP00000165807 antibody; OTTHUMP00000165808 antibody; SHUJUN-1 antibody; smooth muscle isoform antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MYL12B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
  • 基因功能参考文献：
    1. phosphorylated MRLC temporally controls its own accumulation, but not that of actin, in cultured mammalian cells. PMID: 22374324
    2. The study data show that manipulation of the activation sites (Thr18/Ser19) significantly alters myosin II function in a number of these assays while manipulation of the putative inhibitory sites (Ser1/Ser2/Thr9) does not. PMID: 22136066
    3. These results suggest that 2P-MRLC has a role different from that of 1P-MRLC at the midzone, and is not a subunit of myosin II. PMID: 22166199
    4. These results suggest that EGCG inhibits the cell growth by reducing the MRLC phosphorylation and this effect is mediated by the 67LR. PMID: 15946647
  • 组织特异性：
    Ubiquitously expressed in various hematopoietic cells.
  • 数据库链接：

    HGNC: 29827

    KEGG: hsa:103910

    STRING: 9606.ENSP00000237500

    UniGene: Hs.190086