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MYLK2 Antibody

  • 货号：
    CSB-PA189164
  • 规格：
    ￥1100
  • 图片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse muscle tissue, Primary antibody: CSB-PA189164(MYLK2 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q9H1R3
  • 基因名：
  • 别名：
    KMLC antibody; MLCK antibody; MLCK, skeletal/cardiac antibody; MLCK2 antibody; MYLK 2 antibody; MYLK2 antibody; MYLK2_HUMAN antibody; Myosin light chain kinase 2 antibody; Myosin light chain kinase 2 skeletal muscle antibody; Myosin light chain kinase 2 skeletal/cardiac muscle antibody; MYOSIN LIGHT POLYPEPTIDE KINASE antibody; Myosin light polypeptide kinase, skeletal/cardiac antibody; Skeletal muscle myosin light chain kinase antibody; Skeletal myosin light chain kinase antibody; skeletal/cardiac muscle antibody; skMLCK antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human MYLK2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
  • 基因功能参考文献：
    1. the P2X1-ERK2-Myosin Light Chain Kinase axis contributes to collagen-induced platelet activation by enhancing platelet degranulation PMID: 14500714
    2. These data suggest that the kinase domain of MYLK2 is rarely mutated in common human carcinomas and that it does not play a dominant role in cancer pathogenesis. PMID: 16448786
    3. MYLK gene is a risk factor for the development of acute lung injuries. PMID: 18828194
    4. Data show that that the prototypical CaM target sequence skMLCK, a fragment from skeletal muscle myosin light chain kinase, binds to CaM in a highly cooperative way, while only a lower degree of interdomain binding cooperativity emerges for CaMKK. PMID: 19667195
  • 相关疾病：
    Cardiomyopathy, familial hypertrophic (CMH)
  • 亚细胞定位：
    Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  • 组织特异性：
    Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
  • 数据库链接：

    HGNC: 16243

    OMIM: 192600

    KEGG: hsa:85366

    STRING: 9606.ENSP00000365152

    UniGene: Hs.86092