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MYOM1 Antibody

  • 货号：
    CSB-PA964006
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using MYOM1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MYOM1 Polyclonal antibody
  • Uniprot No.：
    P52179
  • 基因名：
    MYOM1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human MYOM1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
  • 基因功能参考文献：
    1. Crystal structure of the obscurin(-like-1):myomesin complex reveals a trans-complementation mechanism whereby an incomplete immunoglobulin-like domain assimilates an isoform-specific myomesin interdomain sequence. PMID: 27989621
    2. individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF-1 splice forms in cultured myoblasts PMID: 25152160
    3. myomesin could act as a highly elastic ribbon to maintain the overall structural organization of the sarcomeric M-band. PMID: 22347812
    4. Our results suggest that the downregulation of MBNL proteins should lead to the abnormal splicing of MYOM1 exon 17a in DM1 muscle. PMID: 21794030
    5. EH-myomesin levels were up-regulated at least 10 times in dilated cardiomyopathy patients compared to controls. PMID: 21069531
    6. This missense mutation caused significant changes of biochemical and biophysical properties of myomesin fragments indicating a role in the pathogenesis of hypertrophic cardiomyopathy . PMID: 21256114
    7. Results identify muscle-type creatine kinase as a binding partner of a central portion of myomesin and the closely related M-protein. PMID: 12972258
    8. visco-elastic properties of myomesin might be crucial for the stability of the sarcomere PMID: 15890201

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  • 亚细胞定位：
    Cytoplasm, myofibril, sarcomere, M line.
  • 数据库链接：

    HGNC: 7613

    OMIM: 603508

    KEGG: hsa:8736

    STRING: 9606.ENSP00000348821

    UniGene: Hs.464469