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MYOZ1 Antibody

  • 货号：
    CSB-PA015365GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NP98
  • 基因名：
    MYOZ1
  • 别名：
    actinin- and telethonin-binding protein antibody; Calsarcin 2 antibody; Calsarcin-2 antibody; CS 2 antibody; FATZ antibody; Filamin, actinin and telethonin binding protein antibody; Filamin- antibody; MYOZ antibody; MYOZ1 antibody; MYOZ1_HUMAN antibody; Myozenin-1 antibody; Protein FATZ antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human MYOZ1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
  • 基因功能参考文献：
    1. Our results implicate MYOZ1 as the causative gene at the chromosome 10q22 locus for AF. PMID: 24177373
    2. Our findings provide evidence for a novel connection between the Z-disc protein calsarcin-2 and the sarcolemma via filamins and beta1 integrins. PMID: 16076904
    3. Mutations in PDLIM3 and MYOZ1, encoding myocyte Z line proteins, do not play any significant role in the genetic etiology of idiopathic DCM. PMID: 17254821
    4. A large number of variations were found in many of the genes (myozenin 1, gamma-filamin, kinectin-1) in patients with limb-girdle muscular dystrophies and controls. PMID: 19472918
  • 亚细胞定位：
    Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.
  • 蛋白家族：
    Myozenin family
  • 组织特异性：
    Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas.
  • 数据库链接：

    HGNC: 13752

    OMIM: 605603

    KEGG: hsa:58529

    STRING: 9606.ENSP00000352272

    UniGene: Hs.238756