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Mlc1 Antibody

  • 货号：
    CSB-PA837739XA01MO
  • 规格：
    ￥880
  • 图片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:Mlc1 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 37 kDa
      Observed band size: 37 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Mlc1 Antibody Polyclonal antibody
  • Uniprot No.：
    Q8VHK5
  • 基因名：
    Mlc1 Antibody
  • 别名：
    Membrane protein MLC1, Mlc1
  • 宿主：
    Rabbit
  • 反应种属：
    Mus musculus (Mouse)
  • 免疫原：
    Recombinant Mus musculus (Mouse) Mlc1 protein (331-382aa)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.
  • 基因功能参考文献：
    1. Mlc1 overexpression reduced activity of the astrocytic sodium pump, which may underlie white matter edema followed by myelin membrane splitting PMID: 27748972
    2. This study demonistrated that Mlc1-null mice replicate the human with megalencephalic leukoencephalopathy with cysts. PMID: 25382142
    3. The complete cDNA sequence, exon-intron organization, and 5'-flanking regulatory region of murine Mlc1 have been reported. PMID: 12658361
    4. Because the temporal expression of Mlc1 indicates that, in contrast to developing and mature astrocytes, oligodendrocytes are devoid of Mlc1 expression, white matter tract abnormalities in these disorders may result from a primary astrocytic defect. PMID: 14603469
    5. Wkl1 is not associated with schizophrenia. PMID: 14755440
    6. Localization and functional analysis of Mlc1 were done in megalocephalic leukoencephalopathy with subcortical cysts. PMID: 15367490
    7. Our data provide a mouse MLC1 expression map that could be useful to understand the phenotype of MLC patients, and suggested that MLC disease is caused by an astrocytic and a neuronal dysfunction PMID: 17434314

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasm, perinuclear region. Endoplasmic reticulum.
  • 数据库链接：

    KEGG: mmu:170790

    STRING: 10090.ENSMUSP00000047667

    UniGene: Mm.32780