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N Antibody

  • 货号：
    CSB-PA318401LA01LNP
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品描述：
    N polyclonal antibody CSB-PA318401LA01LNP was produced in the rabbit immunized by using the Recombinant Lassa virus Nucleoprotein protein (1-569AA) as the immunogen. The target protein N encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). This protein serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses.
    This Rabbit anti-Lassa virus N Polyclonal antibody was tested in the ELISA. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It reacts with the N proteins of lassa virus-origin and may be used to detect the endogenous levels of N protein.
  • 产品名称：
    Rabbit anti-Lassa virus N Polyclonal antibody
  • Uniprot No.：
    P13699
  • 基因名：
  • 别名：
    N antibody; Nucleoprotein antibody; EC 3.1.13.- antibody; Nucleocapsid protein antibody; Protein N antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Lassa virus
  • 免疫原：
    Recombinant Lassa virus Nucleoprotein protein (1-569AA)
  • 免疫原种属：
    Lassa virus
  • 标记方式：
    Non-conjugated

    本页面中的产品，N Antibody (CSB-PA318401LA01LNP)，的标记方式是Non-conjugated。对于N Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA318401LB01LNP N Antibody, HRP conjugated ELISA
    FITC CSB-PA318401LC01LNP N Antibody, FITC conjugated
    Biotin CSB-PA318401LD01LNP N Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.
  • 基因功能参考文献：
    1. Importantly, s demonstrate for the first time that Lassa virus nucleoprotein is involved in the inhibition of antigen-presenting cell-mediated NK cell responses. PMID: 25253342
    2. These results highlight the key role of nucleoprotein exonuclease domain function in the immune evasion that occurs during Lassa virus infection. PMID: 25253344
    3. NP trimerization is essential for transcription and/or replication of the viral genome. PMID: 23553456
    4. molecular dynamics (MD) simulations have been carried out to investigate the characters of deoxythymidine triphosphate binding to two forms of nucleoprotein. PMID: 22871039
    5. Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy PMID: 21917929
    6. Residues D389 and G392 of nucleoprotein were critical for Lassa virus viability, while the D389A/G392A and D389T/392A double mutants were severely altered in the ability to suppress interferon in macrophages and dendritic cells. PMID: 21880754

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  • 亚细胞定位：
    Virion. Host cytoplasm.
  • 蛋白家族：
    Arenaviridae nucleocapsid protein family
  • 数据库链接：

    KEGG: vg:956584