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NAPEPLD Antibody

  • 货号：
    CSB-PA764247LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: NAPEPLD antibody at 6µg/ml
      Lane 1: Mouse large intestine tissue
      Lane 2: Mouse kidney tissue
      Lane 3: Mouse stomach tissue
      Lane 4: MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 46 kDa
      Observed band size: 46 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NAPEPLD Polyclonal antibody
  • Uniprot No.：
    Q6IQ20
  • 基因名：
    NAPEPLD
  • 别名：
    C7orf18 antibody; DKFZp781D1098 antibody; FMP30 antibody; Mbldc1 antibody; N acyl phosphatidylethanolamine hydrolyzing phospholipase D antibody; N acyl phosphatidylethanolamine phospholipase D antibody; N-acyl phosphatidylethanolamine phospholipase D antibody; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D antibody; NAPE hydrolyzing phospholipase D antibody; NAPE-hydrolyzing phospholipase D antibody; NAPE-PLD antibody; NAPEP_HUMAN antibody; NAPEPLD antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D protein (1-200AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NAPEPLD Antibody (CSB-PA764247LA01HU)，的标记方式是Non-conjugated。对于NAPEPLD Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA764247LB01HU NAPEPLD Antibody, HRP conjugated ELISA
    FITC CSB-PA764247LC01HU NAPEPLD Antibody, FITC conjugated
    Biotin CSB-PA764247LD01HU NAPEPLD Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs.
  • 基因功能参考文献：
    1. The AC genotype and C allele of NAPE-PLD rs12540583 locus are risk factors for schizophrenia. PMID: 29652995
    2. NAPE-PLD forms homodimers partly separated by an internal channel and uniquely adapted to associate with phospholipids. PMID: 25684574
    3. our results do not support a clear role of FAAH, CNR1 and NAPE-PLD in BD and lithium response. PMID: 24126189
    4. a major physiological role of NAPE-PLD PMID: 24018423
    5. The differential expression of NAPE-PLD and FAAH suggests that Anandamide could play an important role in the pathophysiology of preeclampsia. PMID: 23122699
    6. NAPE-PLD expression increase steadily after infancy, peaking in adulthood. PMID: 22827915
    7. The results of this study suggested that NAPEPLD was alterated in multip;e sclerosis. PMID: 21251115
    8. a common haplotype in NAPEPLD, an enzyme involved in endocannabinoid synthesis, was protective against obesity. PMID: 20885390
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 20885390
    10. During the menstrual cycle, NAPE-PLD immunoreactivity was down-regulated in the secretory epithelial gland compared to the proliferative epithelial gland and unaffected in the stroma. PMID: 20369362
    11. The human NAPE-PLD was activated by phosphatidylethanolamine and inhibited by the beta-lactamase substrate nitrocefin. PMID: 19715685

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  • 亚细胞定位：
    Golgi apparatus membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Nucleus envelope. Nucleus, nucleoplasm.
  • 蛋白家族：
    NAPE-PLD family
  • 组织特异性：
    Widely expressed. Highest expression in brain, kidney and testis (at protein level). Expressed in adipose tissue (at protein level).
  • 数据库链接：

    HGNC: 21683

    OMIM: 612334

    KEGG: hsa:222236

    STRING: 9606.ENSP00000340093

    UniGene: Hs.324271