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NCAPG Antibody

  • 货号：
    CSB-PA050016
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9BPX3
  • 基因名：
    NCAPG
  • 别名：
    CAPG antibody; CHCG antibody; Chromosome associated protein G antibody; Chromosome condensation protein G antibody; Chromosome-associated protein G antibody; CND3_HUMAN antibody; Condensin complex subunit 3 antibody; Condensin subunit CAP G antibody; Condensin subunit CAP-G antibody; HCAP G antibody; hCAP-G antibody; Melanoma antigen NY MEL 3 antibody; Melanoma antigen NY-MEL-3 antibody; NCAPG antibody; Non SMC condensin I complex subunit G antibody; Non-SMC condensin I complex subunit G antibody; NY MEL 3 antibody; XCAP G homolog antibody; XCAP-G homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human hCAP-G.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
  • 基因功能参考文献：
    1. this study demonstrates that NCAPG plays an important role in the development and progression of hepatocellular carcinoma (HCC), and that it may be a novel therapeutic target for patients with HCC. PMID: 28737823
    2. Data indicate that three genes, KIF14, NCAPG and CENPE that were upregulated in Pediatric high-grade gliomas (pHGGs) and were direct miR-137 or miR-6500-3p targets. PMID: 26933822
    3. Mutation of threonines 308 and 322 to alanines results in defects in CAP-G localization with chromosomes during mitosis. PMID: 18977199
  • 亚细胞定位：
    Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
  • 蛋白家族：
    CND3 (condensin subunit 3) family
  • 组织特异性：
    Highly expressed in testis.
  • 数据库链接：

    HGNC: 24304

    OMIM: 606280

    KEGG: hsa:64151

    STRING: 9606.ENSP00000251496

    UniGene: Hs.567567