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NCKAP1L Antibody

  • 货号：
    CSB-PA015533GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P55160
  • 基因名：
  • 别名：
    4930568P13Rik antibody; AI463083 antibody; HEM1 antibody; Hematopoietic protein 1 antibody; HEMATOPOIETIC PROTEIN HEM-1 antibody; Hemp1 antibody; Membrane associated protein hem1 antibody; Membrane-associated protein HEM-1 antibody; NCK associated protein 1 like antibody; Nck-associated protein 1-like antibody; NCKAP1L antibody; NCKPL_HUMAN antibody
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NCKAP1L
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages. Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells. Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells. Required for efficient T-lymphocyte and neutrophil migration. Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin. Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis. In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF.
  • 基因功能参考文献：
    1. versatile Hem-1-containing complexes coordinate diverse regulatory signals at the leading edge of polarized neutrophils, including but not confined to those involving Verprolin-homologous protein-dependent actin polymerization PMID: 16417406
    2. the Hem-1/Nap1 component of the Scar/WAVE complex localizes to propagating waves that appear to organize the leading edge of a motile neutrophil PMID: 17696648
  • 亚细胞定位：
    Cell membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm.
  • 蛋白家族：
    HEM-1/HEM-2 family
  • 组织特异性：
    Expressed only in cells of hematopoietic origin. Expressed in neutrophils (at protein level). Expressed in T-cells (at protein level).
  • 数据库链接：

    HGNC: 4862

    OMIM: 141180

    KEGG: hsa:3071

    STRING: 9606.ENSP00000293373

    UniGene: Hs.182014