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NCOA6 Antibody

  • 货号：
    CSB-PA015545LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA015545LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NCOA6 Polyclonal antibody
  • Uniprot No.：
    Q14686
  • 基因名：
    NCOA6
  • 别名：
    NCOA6 antibody; AIB3 antibody; KIAA0181 antibody; RAP250 antibody; TRBP antibody; Nuclear receptor coactivator 6 antibody; Activating signal cointegrator 2 antibody; ASC-2 antibody; Amplified in breast cancer protein 3 antibody; Cancer-amplified transcriptional coactivator ASC-2 antibody; Nuclear receptor coactivator RAP250 antibody; NRC RAP250 antibody; Nuclear receptor-activating protein antibody; 250 kDa antibody; Peroxisome proliferator-activated receptor-interacting protein antibody; PPAR-interacting protein antibody; PRIP antibody; Thyroid hormone receptor-binding protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nuclear receptor coactivator 6 protein (285-504AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NCOA6 Antibody (CSB-PA015545LA01HU)，的标记方式是Non-conjugated。对于NCOA6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015545LB01HU NCOA6 Antibody, HRP conjugated ELISA
    FITC CSB-PA015545LC01HU NCOA6 Antibody, FITC conjugated
    Biotin CSB-PA015545LD01HU NCOA6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
  • 基因功能参考文献：
    1. The retinoid x receptor does not interact with the NR box-1 of ASC-2, but functions as an allosteric activator of LXR binding to NR box-2 of ASC-2. PMID: 18031289
    2. diverse physiological function of NCOA6 may be mediated by multiple isoforms expressed in different tissues and localized in different subcellular compartments PMID: 21552418
    3. NCOA6 is responsible for the synergistic activation of CYP2C9 by HNF4alpha and pregnane X receptor and NCOA6 differentially regulates CYP2C9 and CYP3A4 gene expression though both the genes are regulated by the same nuclear receptors. PMID: 21292004
    4. we show that ASC-2 belongs to a steady-state complex of approximately 2 MDa (ASC-2 complex [ASCOM]) in HeLa nuclei. ASCOM contains retinoblastoma-binding protein RBQ-3, alpha/beta-tubulins, and trithorax group proteins ALR-1, ALR-2, HALR, and ASH2. PMID: 12482968
    5. interacts with and stimulates its associated DNA-dependent protein kinase PMID: 12519782
    6. ASC-2 is a physiologically important transcriptional coactivator of LXRs and demonstrate its pivotal role in the liver lipid metabolism PMID: 12724417
    7. ASC-2 appears to contain at least three distinct nuclear receptor interaction domains; also, Rb and ASC-2 have roles in androgen receptor transactivation PMID: 14645241
    8. ASC-2 has a role in inducing target gene transcription during granulocytic differentiation through binding to ATF2 PMID: 14734562
    9. results suggest that ASC-2 is a novel coactivator for HSF1 and heat shock stress may contribute to the strong active transcription complex through sequential recruitment of HSF1 and ASC-2. PMID: 14960326
    10. ASC-2 is a bona fide coactivator of the xenobiotic nuclear receptor CAR and mediate the specific xenobiotic response by CAR in vivo. PMID: 15764585
    11. interaction between RAP250, Smad2, and Smad3 constitutes an important bridging mechanism linking LXR and TGF-beta signaling pathways. PMID: 18263591
    12. AIB3 contributes to the maintenance of beta-cell function in nondiabetic children and regulates gene expression in INS-1 cells. PMID: 18462265
    13. The coactivator NCOA6 mediates the mechanism of the synergistic activation of the CYP2C9 gene by CAR and HNF4alpha. PMID: 18552123
    14. Promoter analysis showed that PRIP acted through serum-responsive factor to regulate FOS gene expression. PMID: 19329434
    15. The activation of DNA-PK in the absence of DNA ends by the coactivator TRBP suggests a novel mechanism of coactivator-stimulated DNA-PK phosphorylation in transcriptional regulation. PMID: 12519782

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.
  • 数据库链接：

    HGNC: 15936

    OMIM: 605299

    KEGG: hsa:23054

    STRING: 9606.ENSP00000351894

    UniGene: Hs.368971