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NDNL2 Antibody

  • 货号：
    CSB-PA289915
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA289915(NDNL2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA289915(NDNL2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, human prostate tissue, A172 cells, mouse liver tissue tissue, Primary antibody: CSB-PA289915(NDNL2 Antibody) at dilution 1/1500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q96MG7
  • 基因名：
    NSMCE3
  • 别名：
    NSMCE3 antibody; HCA4 antibody; MAGEG1 antibody; NDNL2 antibody; Non-structural maintenance of chromosomes element 3 homolog antibody; Non-SMC element 3 homolog antibody; Hepatocellular carcinoma-associated protein 4 antibody; MAGE-G1 antigen antibody; Melanoma-associated antigen G1 antibody; Necdin-like protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human NDNL2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest.
  • 基因功能参考文献：
    1. NSMCE3 (also known as NDNL2) gene encodes a subunit of the SMC5/6 complex that is essential for DNA damage response and chromosome segregation PMID: 27427983
    2. gene expression, imprinting, and chromosome mapping of NDNL2 PMID: 11782285
    3. The four non-SMC components of the human complex were identified and characterized and it was demonstrated that the MAGEG1 protein is part of this complex. PMID: 18086888
  • 相关疾病：
    Lung disease, immunodeficiency, and chromosome breakage syndrome (LICS)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Chromosome, telomere.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 7677

    OMIM: 608243

    KEGG: hsa:56160

    STRING: 9606.ENSP00000330694

    UniGene: Hs.94011