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NDUFS7 Antibody

  • 货号：
    CSB-PA011306
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O75251
  • 基因名：
  • 别名：
    CI 20 antibody; CI-20kD antibody; Complex I 20kDa subunit antibody; Complex I mitochondrial respiratory chain 20 KD subunit antibody; Complex I-20kD antibody; FLJ45860 antibody; FLJ46880 antibody; MGC120002 antibody; MY017 antibody; NADH coenzyme Q reductase antibody; NADH dehydrogenase (ubiquinone) Fe S protein 7 20kDa (NADH coenzyme Q reductase) antibody; NADH dehydrogenase (ubiquinone) FeS protein 7; 20kDa (NADHcoenzyme Q reductase) antibody; NADH dehydrogenase (ubiquinone) FeS protein7; 20kDa (NADHcoenzyme Q reductase) antibody; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7; mitochondrial antibody; NADH-ubiquinone oxidoreductase 20 kDa subunit antibody; NADH:ubiquinone oxidoreductase PSST subunit antibody; NADHcoenzyme Q reductase antibody; Ndufs7 antibody; NDUS7_HUMAN antibody; PSST antibody; PSST subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human NDUFS7.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
  • 基因功能参考文献：
    1. However, similar to another family member, RdmB, it catalyzes the introduction of a hydroxyl group, in the case of NDUFAF5, into Arg-73 in the NDUFS7 subunit of human complex I PMID: 27226634
    2. no active role of NDUFS7 gene in schizophrenia, was found. PMID: 22935918
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
    4. A patient with Leigh syndrome (LS), born to consanguineous parents, with severe complex I defect and a novel mutation in the NDUFS7 gene subunit. PMID: 17275378
    5. Intronic NDUFS7 gene mutation is associated with activation of a cryptic exon and impaired assembly of mitochondrial complex I in a patient with Leigh syndrome PMID: 17604671
    6. Both the amount and intrinsic activity of complex I are decreased in inherited complex I deficiency, ehich can be increased by Trolox. PMID: 18435906
    7. Observational study of gene-disease association. (HuGE Navigator) PMID: 17601350
    8. Observational study of gene-disease association. (HuGE Navigator) PMID: 18977241

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  • 相关疾病：
    Leigh syndrome (LS); Mitochondrial complex I deficiency (MT-C1D)
  • 亚细胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族：
    Complex I 20 kDa subunit family
  • 数据库链接：

    HGNC: 7714

    OMIM: 252010

    KEGG: hsa:374291

    STRING: 9606.ENSP00000233627

    UniGene: Hs.211914