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NECAB3 Antibody

  • 货号：
    CSB-PA000896
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HT29 cells using APBA2BP Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q96P71
  • 基因名：
    NECAB3
  • 别名：
    amyloid beta (A4) precursor protein binding; family A; member 2 binding protein antibody; Amyloid beta A4 protein binding family A member 2 binding protein antibody; Amyloid beta A4 protein-binding family A member 2-binding protein antibody; APBA2BP antibody; dJ63M2.4 antibody; dJ63M2.5 antibody; EFCBP3 antibody; N terminal EF hand calcium binding protein 3 antibody; N-terminal EF-hand calcium-binding protein 3 antibody; NECA3_HUMAN antibody; NECAB3 antibody; Nek2 interacting protein 1 antibody; Nek2-interacting protein 1 antibody; Neuronal calcium binding protein 3 antibody; Neuronal calcium-binding protein 3 antibody; NIP1 antibody; STIP3 antibody; Synaptotagmin interacting protein 2 antibody; SYTIP2 antibody; X11L binding protein 51 antibody; X11L-binding protein 51 antibody; XB51 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human APBA2BP.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3.
  • 基因功能参考文献：
    1. hXB51 isoforms regulate Abeta generation differently, either enhancing it by modifying the association of X11L with APP or suppressing it in an X11L-independent manner PMID: 12780348
    2. xb51 may be required for maturation and maintenance of xb51-expressing neurons in the forebrain PMID: 19035353
  • 亚细胞定位：
    Golgi apparatus.
  • 组织特异性：
    Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas.
  • 数据库链接：

    HGNC: 15851

    OMIM: 612478

    KEGG: hsa:63941

    STRING: 9606.ENSP00000246190

    UniGene: Hs.516986