NEIL1 Antibody

1. NEIL1 and homotetrameric mtSSB form a larger ternary complex in presence of DNA, however, the tetrameric form of mtSSB gets disrupted by NEIL1 in the absence of DNA as revealed by the formation of a smaller NEIL1-mtSSBmonomer complex. PMID: 29522991
2. The major role of acetylable Lys residues in NEIL1 is to stabilize the formation of chromatin-bound repair complexes which protect cells from oxidative stress. PMID: 29698889
3. The level of OGG1 expression was significantly reduced in bipolar patients compared to healthy individuals, whereas the two groups exhibited similar levels of NEIL1 expression. PMID: 29626765
4. identified the c-Jun N-terminal kinase 1 (JNK1) as the kinase involved in the phosphorylation of NEIL1 PMID: 27518429
5. NEIL1 (rs5745908) is associated with Behcet's disease. The genetic association in NEIL1 is a predicted splice donor variant that may introduce a deleterious intron retention and result in a noncoding transcript variant. PMID: 26662719
6. cellular NEIL1 is regulated by the UPP mediated by the E3 ubiquitin ligases Mule and TRIM26, which plays a vital role in co-ordinating the cellular response to DNA damage. PMID: 27924031
7. Nei Like DNA Glycosylase 1 (NEIL1) as a likely candidate gene due to its crucial role in B-cell activation and terminal differentiation. PMID: 28093361
8. NEIL1 and NEIL2 cooperate with TDG during base excision: TDG occupies the abasic site and is displaced by NEILs, which further process the baseless sugar, thereby stimulating TDG-substrate turnover. PMID: 26751644
9. first study to show that SNPs of genes involved in DNA repair, may modulate the risk of Depressive Disorder. PMID: 26074017
10. Findings suggesting that DNA glycosylase NEIL1 c.C844T is a defective allele. PMID: 26095805
11. NEIL1 forms a multiprotein complex with DNA replication proteins via its C-terminal domain, allowing recruitment at the replication fork. PMID: 26134572
12. Results show that YB-1 interferes negatively with the AP site DNA cleavage activity of both APE1 and NEIL1 for ssDNA and bubble structures. PMID: 25605055
13. Rad9 regulates base excision repair by controlling NEIL1 transcription. PMID: 25873625
14. genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase PMID: 24382305
15. The NEIL1 rs4462560 SNP may serve as a predictor of acute RIET and RP risk but not of overall survival. PMID: 24022861
16. Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins. PMID: 23898192
17. s show that the intrinsically disordered C-terminal domain interacts with the folded domain in native NEIL1 containing 389 residues. PMID: 23542007
18. NEIL1 recognizes specifically and distinctly interstrand crosslinks in DNA, and can obstruct the efficient removal of lethal crosslink adducts. PMID: 23508956
19. binds to the BRCT domain of PARP-1 PMID: 23104860
20. aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma PMID: 22286769
21. NEIL1 gene mutation may have a causative role in the development of type 2 diabetes in the Turkish population. PMID: 21985917
22. we demonstrated that hNEIL1 and hNTH1 cleave Oz sites as efficiently as 5-hydroxyuracil sites. Thus, hNEIL1 and hNTH1 can repair Oz lesions PMID: 22465744
23. the hnRNP-U protection of cells after oxidative stress is largely due to enhancement of NEIL1-mediated repair. PMID: 22902625
24. Pro2 and Lys54 are involved in the AP lyase activity; Met81, Arg119 and Phe120 are essential for removal of 8-oxoG in duplex DNA PMID: 22858590
25. the binding of these modified DNAs with the unedited and edited forms of human NEIL1 along with E. coli Endo III PMID: 22639086
26. Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA. PMID: 22170059
27. Homozygosity mapping and exome sequencing in a consanguineous kindred identified MYO1E and NEIL1 as novel candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome. PMID: 21697813
28. These data suggest Neil1 may be a critical mediator of base excision repair of incorporated dUMP following thymidylate synthetase pathway inhibition. PMID: 21131780
29. enzymological activity in peripheral leukocytes is increased in children with asthma bronchiale PMID: 19840299
30. NEIL1 recoding site is a preferred editing site for the RNA editing adenosine deaminase ADAR1. PMID: 21068368
31. WRN is the only human RecQ helicase that stimulates NEIL1 DNA glycosylase activity, and that this stimulation requires a double-stranded DNA substrate. PMID: 20346739
32. Modulation of NEIL1's activity on single-stranded DNA substrate by RPA and PCNA support NEIL1's involvement in repairing the replicating genome. PMID: 20338831
33. These results suggest that, in vivo, NEIL1 functions either at nucleosome-free regions (such as those near replication forks) or with cofactors that limit its non-specific binding to DNA. PMID: 20005182
34. The results indicate that NEIL1 does not require a base opposite to identify and remove hydantoin lesions. PMID: 20099873
35. Pyrimidine dimer repair enzyme located on the long arm of chromosome 15 that is frequently deleted in human cancers. PMID: 12509226
36. NEIL1 and NEIL2 are preferentially involved in repair of lesions in DNA bubbles generated during transcription and/or replication PMID: 14522990
37. hNEIL1 has a significant role in the repair of 5S-Tg in human cells. PMID: 14734554
38. Overproduction, crystallization and preliminary crystallographic analysis of NEIL1 PMID: 15159582
39. zincless finger appears to be required for NEIL1 activity, because mutating a very highly conserved arginine within this motif greatly reduces the glycosylase activity of the enzyme. PMID: 15232006
40. Reduced expression of NEIL1 is associated with the pathogenesis of gastric cancers PMID: 15319300
41. NEIL1 and OGG1, two DNA glycosylases which do not stably interact with each other, stimulate 8-oxoguanine repair by a collaboration that is possible because of higher abasic (AP) site affinity and stronger AP lyase activity of NEIL1 relative to OGG1. PMID: 15350146
42. NEIL1 is a DNA glycosylase that excise 5-formyluracil, 5-hydroxymethyluracil and Thymine glycol in human cells. PMID: 15533839
43. Oxidative stress-induced activation of NEIL1 appears to be involved in the feedback regulation of cellular repair activity needed to handle an increase in the level of oxidative base damage PMID: 16118226
44. Nth1 released 5R,6S 2'-deoxyribonucleoside diastereoisomer (Tg2) much more rapidly than cis 5S,6R-deoxyribonucleoside diastereoisomer (Tg1) regardless of the opposing purine. Neil1 released Thymine glycol non-stereoselectively. PMID: 16446124
45. A T434+2C mutation was found in familial colorectal cancer DNA suggesting a limited role for this gene in the devlopment of CRC. PMID: 17029639
46. The damage specificity of human homologues of Endo III (hNTHl) and Endo VIII (hNEIL1 and hNEIL2) is compared to elucidate the repair role in cells. PMID: 17150535
47. we found that although both SMUG1 and NEIL1 are able to excise 5-OHU lesions located in the proximity of the proximity of the 3'-end of a DNA SSB, NEIL1 is more efficient in the repair of these DNA lesions. PMID: 17348689
48. Human NEIL1 DNA glycosylase activity is significantly stimulated by hHus1, hRad1, hRad9 separately and by the 9-1-1 complex. PMID: 17395641
49. The ability of Neil1 to recognize a variety of pyrimidine lesions is connected to the flexible binding pocket of the enzyme and the common chemical features of lesions that contain a pyrimidine ring. PMID: 17432829
50. Centrosomal localization of hNEIL1 was observed when mitotic HeLa cells were immunostained with hNEIL1 antibodies PMID: 17556049

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HGNC: 18448

OMIM: 608844

KEGG: hsa:79661

STRING: 9606.ENSP00000347170

UniGene: Hs.512732