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NELFCD Antibody

  • 货号：
    CSB-PA023471GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8IXH7
  • 基因名：
  • 别名：
    HSPC130 antibody; Negative elongation factor C/D antibody; NELF C antibody; NELF D antibody; NELF-C/D antibody; NELFC antibody; NELFD antibody; NELFD_HUMAN antibody; TH1 antibody; TH1-like protein antibody; TH1L antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TH1L
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.
  • 基因功能参考文献：
    1. Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration. PMID: 22238675
    2. TH1 might play an important role in regulation of proliferation and invasion in human breast cancer. PMID: 20735431
    3. These results indicate that TH1 is a novel regulator to control the duration and magnitude of androgen signal transduction and might be directly involved in androgen-related developmental, physiological, and pathological processes. PMID: 20069563
    4. diverse transcriptional consequence of NELF-mediated RNAPII pausing in the human genome PMID: 20028984
    5. In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf. PMID: 11952167
    6. Trihydrophobin 1 negatively regulates A-Raf kinase PMID: 14684750
    7. A study was done of ubiquitin-dependent proeolysis of TH1L protein by E6-AP. PMID: 17131388
    8. Maternal serum Th1 cytokines concentrations increase in preterm and term delivery. PMID: 17621989
    9. TH1 interacts with PAK1 and specifically restricts the activation of MAPK modules through the upstream region of the MAPK pathway, thereby influencing cell migration. PMID: 19136554

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NELF-D family
  • 组织特异性：
    Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.
  • 数据库链接：

    HGNC: 15934

    OMIM: 605297

    KEGG: hsa:51497

    STRING: 9606.ENSP00000342300

    UniGene: Hs.517148