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  4. NEUROG1 Antibody

NEUROG1 Antibody

  • 货号：
    CSB-PA100644
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA100644(NEUROG1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue, Primary antibody: CSB-PA100644(NEUROG1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q92886
  • 基因名：
  • 别名：
    AKA antibody; Ath4c antibody; bHLHa6 antibody; Class A basic helix-loop-helix protein 6 antibody; Helix loop helix protein mATH 4C antibody; MATH4C antibody; NeuroD3 antibody; Neurog 1 antibody; Neurog1 antibody; Neurogenic basic helix loop helix protein antibody; Neurogenic basic-helix-loop-helix protein antibody; Neurogenic differentiation 3 antibody; Neurogenic differentiation factor 3 antibody; Neurogenin-1 antibody; Neurogenin1 antibody; Ngn antibody; NGN-1 antibody; Ngn1 antibody; NGN1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human NEUROG1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.
  • 基因功能参考文献：
    1. mutation not found in group of children with sensorineural hearing loss PMID: 26634621
    2. Results show that neurogenin-1 and -2 drive homogeneous differentiation of human stem cells into bipolar neurons in 4 days in defined media. PMID: 25403753
    3. We propose NEUROG1 as a new gene for syndromic autosomal recessive hearing loss and congenital cranial dysinnervation disorder PMID: 23419067
    4. Methylation of NEUROG1 is associated with recurrence following adjuvant FOLFOX in Stages II/III colorectal cancer. PMID: 23034738
    5. NEUROG1 gene is frequently found in patients, diagnosed with colorectal cancer. PMID: 21326223
    6. Stable expression of a single gene Ngn1 in F3 cells induces not simply neurogenic but multifunctional changes that potentially affect the differentiation of human NSC via a reorganization of complex gene regulatory networks. PMID: 19813087
    7. The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding. PMID: 20102160
    8. Overexpression of the full-length Ngn1 induced neurite outgrowth in F11 cells in the absence of cAMP PMID: 12526089
    9. These results, along with a priori evidence for the involvement of neurog1 in neurodevelopment, suggest that variants in neurog1 might have a small effect on susceptibility to schizophrenia. PMID: 17044100
    10. Major alleles on two NEUROG1-associated SNPs (rs2344484-C-allele and rs8192558-G-allele) were significantly more prevalent among patients. this is the first study to examine brain morphological and neurocognitive correlates of NEUROG1. PMID: 18799289

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expression restricted to the embryonic nervous system.
  • 数据库链接：

    HGNC: 7764

    OMIM: 601726

    KEGG: hsa:4762

    STRING: 9606.ENSP00000317580

    UniGene: Hs.248149