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NFE2L3 Antibody

  • 货号：
    CSB-PA003485
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using Nrf3 Polyclonal Antibody
    • Western Blot analysis of K562 NIH-3T3 cells using Nrf3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y4A8
  • 基因名：
    NFE2L3
  • 别名：
    NFE2L3 antibody; NRF3 antibody; Nuclear factor erythroid 2-related factor 3 antibody; NF-E2-related factor 3 antibody; NFE2-related factor 3 antibody; Nuclear factor antibody; erythroid derived 2 antibody; like 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Nrf3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activates erythroid-specific, globin gene expression.
  • 基因功能参考文献：
    1. SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM. PMID: 28554271
    2. findings reveal FBW7 and GSK3 as novel regulators of the NFE2L3 transcription factor and a potential mechanism by which FBW7 might regulate detoxification and the cellular response to stress PMID: 26306035
    3. 17beta-Estradiol treatment significantly increased but VC or Res decreased Nrf3 mRNA and protein expression levels. PMID: 25130429
    4. Nrf3 is a negative regulator of ARE-mediated gene expression of NQO1 PMID: 15385560
    5. NRF3 is highly expressed in primary placental cytotrophoblasts PMID: 15388789
    6. Nrf3 is an N-glycosylated protein associated with the endoplasmic reticulum PMID: 17976382

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, CNC subfamily
  • 组织特异性：
    Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 7783

    OMIM: 604135

    KEGG: hsa:9603

    STRING: 9606.ENSP00000056233

    UniGene: Hs.404741