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NFRKB Antibody

  • 货号：
    CSB-PA003423
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COS7 cells using NFRκB Polyclonal Antibody
    • Western Blot analysis of various cells using NFRκB Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q6P4R8
  • 基因名：
    NFRKB
  • 别名：
    NFRKB antibody; INO80G antibody; Nuclear factor related to kappa-B-binding protein antibody; DNA-binding protein R kappa-B antibody; INO80 complex subunit G antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NFRκB.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.
  • 基因功能参考文献：
    1. Data show that DEUBAD domain in RPN13 (ADRM1) activates ubiquitin thioesterase L5 (UCH-L5), and the related DEUBAD domain in INO80G (NFRKB) inhibits UCH-L5. PMID: 25702870
    2. The structure of a novel helical domain of NFRKB was determined to 2.18 A resolution. PMID: 22984442
    3. NFRKB may be involved in the disorders of transcriptional regulation commonly observed in minimal change nephrotic syndrome relapse. PMID: 22291976
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NFRKB family
  • 组织特异性：
    Expressed in thymus, brain, testes, spleen and liver.
  • 数据库链接：

    HGNC: 7802

    OMIM: 164013

    KEGG: hsa:4798

    STRING: 9606.ENSP00000436926

    UniGene: Hs.530539