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NFYB Antibody

  • 货号：
    CSB-PA003425
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using NF-YB Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P25208
  • 基因名：
  • 别名：
    CAAT box DNA binding protein subunit B antibody; CAAT box DNA-binding protein subunit B antibody; CBF A antibody; CBF B antibody; CCAAT binding transcription factor subunit A antibody; HAP 3 antibody; HAP3 antibody; NF Y protein chain B antibody; NF YB antibody; NF-YB antibody; NFYB antibody; NFYB_HUMAN antibody; Nuclear transcription factor Y beta antibody; Nuclear transcription factor Y subunit B antibody; Nuclear transcription factor Y subunit beta antibody; Transcription factor NF Y B subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human NF-YB.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
  • 基因功能参考文献：
    1. The nuclear transcription factor Y subunit beta (NFYB)-E2F transcription factor 1 (E2F1) pathway displays a crucial role in the chemoresistance ofoxaliplatin-resistant colorectal cancer (OR-CRC) by inducing the expression and activation of checkpoint kinase 1 (CHK1), suggesting a possible therapeutic target for oxaliplatin resistance in CRC. PMID: 29203250
    2. NF-YB transcription factor was identified as a novel direct E2F1 target. PMID: 26039627
    3. The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif. PMID: 23595228
    4. Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in acute myeloid leukemia. PMID: 22132193
    5. NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L PMID: 21445285
    6. MicroRNA-485-3p regulates drug responsiveness by decreasing nuclear factor-YB expression, which in turn negatively regulates DNA topoisomerase IIalpha. PMID: 21252292
    7. The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. PMID: 12401788
    8. CBF/NF-Y proteins regulate the transcription of COL11A1 by directly binding to the ATTGG sequence in the proximal promoter region PMID: 12805369
    9. Co-operative functional interactions between Sp1 & NF-Y are required to direct the activity of the ATP1A3 promoter predominantly in neuronal cells. PMID: 15462673
    10. trichostatin A activates the transcription of TSP1 gene through the binding of transcription factor CBF to CCAAT box and the enhanced histone acetylation. PMID: 18275041
    11. CBF-A is a novel transacting factor required for cytoplasmic mRNA transport and localization PMID: 18480411

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NFYB/HAP3 subunit family
  • 数据库链接：

    HGNC: 7805

    OMIM: 189904

    KEGG: hsa:4801

    STRING: 9606.ENSP00000240055

    UniGene: Hs.84928