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NFYC Antibody

  • 货号：
    CSB-PA015775GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q13952
  • 基因名：
  • 别名：
    CAAT box DNA binding protein subunit C antibody; CAAT box DNA-binding protein subunit C antibody; CBF C antibody; CBFC antibody; CCAAT binding factor subunit C antibody; CCAAT transcription binding factor subunit gamma antibody; DKFZp667G242 antibody; FLJ45775 antibody; H1TF2A antibody; HAP5 antibody; histone H1 transcription factor large subunit 2A antibody; HSM antibody; NF-YC antibody; NFYC antibody; NFYC_HUMAN antibody; Nuclear transcription factor Y gamma antibody; Nuclear transcription factor Y subunit C antibody; Nuclear transcription factor Y subunit gamma antibody; OTTHUMP00000009207 antibody; OTTHUMP00000009208 antibody; OTTHUMP00000009209 antibody; OTTHUMP00000009210 antibody; OTTHUMP00000009211 antibody; OTTHUMP00000009212 antibody; OTTHUMP00000009213 antibody; OTTHUMP00000009215 antibody; OTTHUMP00000009217 antibody; OTTHUMP00000231028 antibody; Transactivator HSM 1/2 antibody; transactivator HSM-1 antibody; Transactivator HSM-1/2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NFYC
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
  • 基因功能参考文献：
    1. NF-YC was significantly increased in gliomas. Knockdown of NF-YC reduced brain tumor size in vivo. NF-YC played as an independent predictor of patient survival. PMID: 27495011
    2. p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. PMID: 28257042
    3. TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair PMID: 25965574
    4. the expression of the adipogenic differentiation genes fatty acid binding protein-4, adiponectin, and leptin and the formation of fat droplets were impaired. PMID: 23657974
    5. NFY-C expression was elevated in colorectal adenocarcinomas; moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease PMID: 22104449
    6. Sp1, NF-Y and FOXO transcription factors are involved in the regulation of LKB1 transcription. PMID: 22412893
    7. NF-YC functions as a new corepressor of agonist-bound mineralocorticoid receptor via alteration of aldosterone-induced MR conformation PMID: 20054001
    8. role in repressing Smad2 and Smad3 transactivating activity PMID: 12023901
    9. C/EBPbeta contributes to the induction of hepatocyte replication in response to HGF in rodents, which is likely due to post-translational modifications. PMID: 15922473
    10. Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple neoplasms. PMID: 19559782
    11. NF-YC complexity is generated by dual promoters and alternative splicing PMID: 19690168

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NFYC/HAP5 subunit family
  • 数据库链接：

    HGNC: 7806

    OMIM: 605344

    KEGG: hsa:4802

    STRING: 9606.ENSP00000396620

    UniGene: Hs.713051