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NHP2L1 Antibody

  • 中文名称：
    NHP2L1兔多克隆抗体
  • 货号：
    CSB-PA015794GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P55769
  • 基因名：
    SNU13
  • 别名：
    SNU13 antibody; NHP2L1 antibody; NHP2-like protein 1 antibody; High mobility group-like nuclear protein 2 homolog 1 antibody; OTK27 antibody; SNU13 homolog antibody; hSNU13 antibody; U4/U6.U5 small nuclear ribonucleoprotein SNU13 antibody; U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1 antibody; N-terminally processed] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NHP2L1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.
  • 基因功能参考文献：
    1. Results solve the structure of a complex resulting from interaction between protein fragments of human NUFIP1 and its cofactor ZNHIT3, and emphasize their imbrication. Also, it seems that the complexes involving NUFIP1, ZNHIT3, and SNU13 share strong structural similarities between human and yeast, suggesting that the initial steps of the box C/D snoRNP assembly process are conserved among species. PMID: 27594683
    2. NHPX is specifically accumulated in both nucleoli and Cajal bodies (CBs) in vivo. The data show a specific temporal pathway involving the sequential and directed accumulation of NHPX in distinct subnuclear compartments PMID: 12011111
    3. the testis-specific expression of FA-1 antigen at the mRNA level PMID: 12203836
    4. Data show that binding of the 15.5 kD RNA binding protein to the box C/D motif of snoRNAs is essential for the association of other snoRNP-associated proteins. PMID: 12417735
    5. describe the solution NMR structure of free 15.5K, as well as studies of conformational flexibility from 15N NMR relaxation and H/D exchange experiments PMID: 18044964
    6. snoRNP assembly factor NUFIP can regulate the interactions between TIP48 and TIP49 and the core box C/D proteins. PMID: 19620283

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  • 亚细胞定位：
    Nucleus. Nucleus, nucleolus.
  • 蛋白家族：
    Eukaryotic ribosomal protein eL8 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 7819

    OMIM: 601304

    KEGG: hsa:4809

    STRING: 9606.ENSP00000215956

    UniGene: Hs.182255