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NIN Antibody

  • 货号：
    CSB-PA843155LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA843155LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NIN Polyclonal antibody
  • Uniprot No.：
    Q8N4C6
  • 基因名：
  • 别名：
    Centrosome Marker antibody; Glycogen synthase kinase 3 beta interacting protein antibody; GSK3B interacting protein antibody; h Glycogen synthase kinase 3 beta-interacting protein antibody; hNinein antibody; KIAA1565 antibody; NIN antibody; NIN protein antibody; NIN_HUMAN antibody; ninein (GSK3B interacting protein) antibody; Ninein antibody; Ninein centrosomal protein antibody; SCKL7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ninein protein (80-185AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NIN Antibody (CSB-PA843155LA01HU)，的标记方式是Non-conjugated。对于NIN Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA843155LB01HU NIN Antibody, HRP conjugated ELISA
    FITC CSB-PA843155LC01HU NIN Antibody, FITC conjugated
    Biotin CSB-PA843155LD01HU NIN Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Required for centriole organization and microtubule anchoring at the mother centriole.
  • 基因功能参考文献：
    1. Our analyses suggest a relationship with prenatal neurogenesis and identify the human data point as an outlier, possibly explained by postnatal changes in development on the human lineage. PMID: 22937743
    2. Ninein influences the rate of axonal growth and branching by affecting microtubule stability and dynamics. PMID: 25741725
    3. JAK2 Tyrosine Kinase phosphorylates centrosomal protein ninein, which negatively regulates it PMID: 25332239
    4. A Ninein (NIN) missense mutation identified in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. PMID: 23665482
    5. The role of hNinein isoform 6 expression in cell differentiation was assessed in BrdU-treated IMR-32 cells PMID: 23047184
    6. The prevalence of hNinein autoreactivity and its specificity in 22 rheumatoid arthritis and 32 systemic lupus erythematosus autoimmune disease sera. PMID: 21667027
    7. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. PMID: 21325031
    8. Two single nucleotide polymorphisms in the APC and NIN loci were significantly associated with pancreatic cancer risk PMID: 20056645
    9. Ninein is essential for the reformation of specific aspects of the interphase centrosome architecture following mitosis as well as being required for the centrosome to function as a MTOC. PMID: 11956314
    10. ninein protein has two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle PMID: 12927815
    11. Elevated ninein causes mislocalization of gamma-tubulin, recruiting it to ectopic (noncentrosomal) ninein-containing sites which are not active in nucleating microtubules, suggesting a regulatory role for ninein in microtubule nucleation. PMID: 15190203
    12. We propose that ninein constitutes a molecular link between microtubule-nucleation and -anchoring activities at the centrosome. PMID: 15784680
    13. our findings place SUMOylation target on the centrosome structure protein, hNinein, which results in the switch localization from centrosome to nucleus PMID: 16154161
    14. analysis of human ninein isoforms that are regulated by centrosomal targeting signals and bind to gamma-tubulin PMID: 17102634
    15. hNinein regulates the dynamic movement of Astrin throughout the cell cycle and this interaction, in turn, is required for maintenance of centrosome/spindle pole integrity. PMID: 17383637
    16. Data show that ninein is highly dynamic and that, in epithelial cells, it is present not only at the centrosome but also in the cytoplasm as distinct speckles. PMID: 17698918

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  • 相关疾病：
    Seckel syndrome 7 (SCKL7)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.; [Isoform 6]: Cytoplasm.
  • 组织特异性：
    Ubiquitous. Highly expressed in heart and skeletal muscle. Isoform 1 is more expressed than isoform 5.
  • 数据库链接：

    HGNC: 14906

    OMIM: 608684

    KEGG: hsa:51199

    STRING: 9606.ENSP00000371472

    UniGene: Hs.310429