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NISCH Antibody

  • 货号：
    CSB-PA015821DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA015821DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA015821DSR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NISCH Polyclonal antibody
  • Uniprot No.：
    Q9Y2I1
  • 基因名：
    NISCH
  • 别名：
    NISCH antibody; IRAS antibody; KIAA0975 antibody; Nischarin antibody; Imidazoline receptor 1 antibody; I-1 antibody; IR1 antibody; Imidazoline receptor antisera-selected protein antibody; hIRAS antibody; Imidazoline-1 receptor antibody; I1R antibody; Imidazoline-1 receptor candidate protein antibody; I-1 receptor candidate protein antibody; I1R candidate protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nischarin protein (500-700AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
  • 基因功能参考文献：
    1. These experiments demonstrate an important role of Nischarin in regulating cell attachment, which adds to our understanding of the early events of the metastatic process in breast cancer. PMID: 29415725
    2. In the prefrontal cortex of long-term opiate/cocaine abusers, IRAS content was increased when compared to matched controls. PMID: 28461172
    3. IRAS is a new mu opioid receptor interacting protein that regulates agonist-induced trafficking of mu opioid receptor. PMID: 26363797
    4. The present data confirmed that Nishcharin might be a novel tumor suppressor and plays an important role in breast cancer cell apoptosis and metastasis, which can be used as a potential therapeutic target for breast cancer treatment. PMID: 28131840
    5. Data found that NISCH was significantly downregulated in ovarian neoplasm through its promotor silencing with hypermethylation and its expression was correlated with poor prognosis. PMID: 25724667
    6. Nischarin expression may therefore be used as a marker to predict the invasiveness and metastasis of primary breast cancer PMID: 25695373
    7. Tobacco smoke induces methylation changes in the NISCH gene promoter before any detectable cancer. PMID: 23503203
    8. unctional interaction between LKB1 and Nischarin to inhibit cell migration and breast tumor progression PMID: 23572524
    9. Imidazoline receptor 1 gene plays a role in the development of cardiac hypertrophy and ventirular remodeling. PMID: 22483786
    10. Nischarin reduces alpha5 integrin expression leading to reduction of FAK phosphorylation and Rac GTP loading, which in turn reduces tumor growth. NISCH also regulates PAK and LIMK signaling. PMID: 21917605
    11. Insulin receptor substrate 4 associates with the protein IRAS (IRAS protein) PMID: 11912194
    12. The heart possesses imidazoline I1-receptors that are up-regulated in the presence of hypertension or heart failure, which suggests their involvement in cardiovascular regulation. PMID: 12021582
    13. I(1)-receptors can abrogate the primary signaling cascade activated by NGF, most likely by increasing levels of a specific phosphatase to return dually phosphorylated ERK to its unphosphorylated state. PMID: 12865160
    14. hIRAS expression in PC12 cells resulted in protection against apoptosis PMID: 12868002
    15. Results suggest that IRAS may represent a previously unknown anti-apoptotic protein involved in the regulation of cell survival. PMID: 15028619
    16. Results describe three alternatively spliced transcripts of the human I(1)-imidazoline receptor candidate gene, IRAS. PMID: 15028621
    17. Results suggest that imidazoline-1 receptors (I(1)R) and alpha(2)-noradrenergic receptors (alpha(2)AR) may interact with each other. PMID: 15028622
    18. platelets lacked the 170-kD form of IRAS, but 33-kD and 85-kD bands were detectable and seemed to be possible fragments of full-length IRAS PMID: 15028623
    19. PX domain of imidazoline receptor antisera-selected protein(IRAS) is essential for association with phosphatidylinositol 3-phosphate-enriched endosomal membranes but is insufficient without coiled-coil domain PMID: 15475348
    20. The signaling pathway of IRAS in response to I1R agonists coupled with the activation of PC-PLC and its downstream signal transduction molecule, ERK. These findings are similar to those in the signaling pathways of native I1R. PMID: 16598778
    21. shows strong affinity to clonidine and regulates blood pressure. PMID: 18561481

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  • 亚细胞定位：
    Cell membrane. Cytoplasm. Early endosome. Recycling endosome.
  • 组织特异性：
    Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrine tissues.
  • 数据库链接：

    HGNC: 18006

    OMIM: 615507

    KEGG: hsa:11188

    STRING: 9606.ENSP00000339958

    UniGene: Hs.435290