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NKD1 Antibody

  • 货号：
    CSB-PA853369LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat heart tissue
      All lanes: NKD1 antibody at 1.8μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 53 kDa
      Observed band size: 53 kDa
    • Immunofluorescence staining of HepG2 cells with CSB-PA853369LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NKD1 Polyclonal antibody
  • Uniprot No.：
    Q969G9
  • 基因名：
  • 别名：
    NKD1 antibody; NKD antibody; PP7246 antibody; Protein naked cuticle homolog 1 antibody; Naked-1 antibody; hNkd antibody; hNkd1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Protein naked cuticle homolog 1 protein (269-384AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NKD1 Antibody (CSB-PA853369LA01HU)，的标记方式是Non-conjugated。对于NKD1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA853369LB01HU NKD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA853369LC01HU NKD1 Antibody, FITC conjugated
    Biotin CSB-PA853369LD01HU NKD1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.
  • 基因功能参考文献：
    1. the downregulation of NKD1 may be involved in the proliferation and migration of osteosarcoma cells through the activation of the canonical Wnt signaling pathway. PMID: 29115501
    2. The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocellular carcinoma cells. PMID: 27231134
    3. HNF1A-AS1 promoted HCC cell proliferation by repressing the NKD1 and p21 expression. PMID: 28292020
    4. Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744. PMID: 28107193
    5. NKD1 showed significantly increased level after induction chemotherapy achieved complete remission in follow-up paired acute myeloid leukemia patients ( p < 0.001). These findings indicated that reduced NKD1 expression is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia. PMID: 28443469
    6. Low NKD1 expression is associated with hepatocellular carcinoma. PMID: 27507614
    7. Silencing of NKD1 significantly inhibited the proliferation and invasion of osteosarcoma cells. PMID: 28032380
    8. Suggest that NKD1 plays an important role in invasion in human breast cancer and it appears to be a potential prognostic marker for patients with breast cancer. PMID: 26097589
    9. Reduced NKD1 protein expression correlates with a poor prognosis in NSCLC PMID: 21599923
    10. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling PMID: 19956716

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  • 亚细胞定位：
    Cell membrane. Cytoplasm.
  • 蛋白家族：
    NKD family
  • 组织特异性：
    Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.
  • 数据库链接：

    HGNC: 17045

    OMIM: 607851

    KEGG: hsa:85407

    STRING: 9606.ENSP00000268459

    UniGene: Hs.187578