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NKX6-3 Antibody

  • 货号：
    CSB-PA007583
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using Nkx-6.3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    A6NJ46
  • 基因名：
    NKX6-3
  • 别名：
    FLJ25169 antibody; Homeobox protein Nkx 6.3 antibody; Homeobox protein Nkx-6.3 antibody; NK6 homeobox 3 antibody; NKX6-3 antibody; NKX6.3 antibody; NKX63 antibody; NKX63_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Nkx-6.3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.
  • 基因功能参考文献：
    1. these results suggest that NKX6.3 inhibits ROS production by inducing the expression of Hace1 via down-regulating NF-kB and DNMT1 activity in gastric epithelial cells. PMID: 28584243
    2. The expression level of NKX6.3 is involved in regulation of gastric cancer progression and expression of Wnt/beta-catenin and Rho-GTPase pathway-related genes in clinical samples. PMID: 27333045
    3. Suggest that NKX6.3 might function as a master regulator of gastric differentiation by affecting SOX2 and CDX2 expression and the NKX6.3 inactivation may result in intestinal metaplasia in gastric epithelial cells. PMID: 26743476
    4. Data suggest that NK6 homeobox 3 (NKX6.3) may control the fate of gastric mucosal cells and function as a gastric tumor suppressor. PMID: 26314965
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 26328

    OMIM: 610772

    KEGG: hsa:157848

    STRING: 9606.ENSP00000429553