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NLRX1 Antibody

  • 货号：
    CSB-PA770306
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HEPG2 Hela cells using NLRX1 Polyclonal Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000
    • Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q86UT6
  • 基因名：
  • 别名：
    Caterpiller protein 11.3 antibody; CLR11.3 antibody; DLNB26 antibody; FLJ21478 antibody; MGC131937 antibody; MGC21025 antibody; NLR family member X1 antibody; NLR family, X1 antibody; Nlrx1 antibody; NLRX1_HUMAN antibody; NOD-like receptor X1 antibody; NOD26 antibody; NOD5 antibody; NOD9 antibody; Nucleotide-binding oligomerization domain protein 26 antibody; Nucleotide-binding oligomerization domain protein 5 antibody; Nucleotide-binding oligomerization domain protein 9 antibody; nucleotide-binding oligomerization domain, leucine rich repeat containing X1 antibody; Protein Caterpiller 11.3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from NLRX1 at AA range: 581-630
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-2000
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species.
  • 基因功能参考文献：
    1. Data show that NLRX1 specifically interacts with FASTKD5 and colocalizes with mitochondrial RNA granules. Further results suggest an important role of NLRX1 in regulating the post-transcriptional processing of mitochondrial RNA, which may have an important implication in bioenergetic adaptation during metabolic stress, oncogenic transformation and innate immunity. PMID: 29932989
    2. genetic association studies in Han population in southern China: Data suggest that, in subjects with type 2 diabetes, an SNP in NLRX1 (rs4245191) is associated with macro-vascular complications and cerebral infarction in the population studied; no such association was found for two other SNPs in NLRX1 (rs10790286, rs561830) or for two SNPs in TRAF6 (rs5030445, rs16928973). (TRAF6 = TNF receptor associated factor-6) PMID: 29046236
    3. Data show that NLRX1 suppresses tumorigenesis and reveals new genetic pathways involved in the pathobiology of histiocytic sarcoma. PMID: 27105514
    4. NLRX1 exerted opposing regulatory effects on viral activation of the transcription factors IRF1 and IRF3. NLRX1 suppressed MAVS-mediated activation of IRF3, it conversely facilitated virus-induced increases in IRF1 expression and thereby enhanced control of viral infection. PMID: 28967880
    5. downregulated in brain injury following aneurysm PMID: 28993512
    6. The data suggests that NLRX1 plays a positive role in Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by suppressing the IFNbeta response during the process of KSHV reactivation, which might serve as a potential target for restricting KSHV replication and transmission. PMID: 28459883
    7. we identify a novel signaling hub centering on the NLRX1 TUFM protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM result in compromised autophagy when treated with EGFR inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR inhibitors. PMID: 26876213
    8. findings suggest that NLRX1 may function as a cardiac-protective molecule in myocardial ischemic injury by repressing inflammation and apoptosis PMID: 27393910
    9. NLRX1, NLRP12 and NLRC3 negatively modulate the host immune response following virus exposure. (Review) PMID: 26763980
    10. NLRX1 acts as a potential tumor suppressor by regulating the TNF-alpha induced cell death and metabolism. PMID: 25639646
    11. These data support a model in which CS-dependent NLRX1 inhibition facilitates MAVS/RHL activation and subsequent inflammation, remodeling, protease, cell death, and inflammasome responses. PMID: 25938787
    12. Together, these results suggest a novel mechanism for rhinovirus-induced epithelial barrier disruption involving NLRX-1 and mitochondrial reactive oxygen species generation. PMID: 24429360
    13. NLRX1 and TUFM work in concert to reduce cytokine response and augment autophagy. PMID: 23321557
    14. Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B. PMID: 22610944
    15. Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3. PMID: 22718770
    16. NLRX1 attenuated IFN-I production & promoted autophagy during viral infection cells. NLRX1 interacts with TUFM. PMID: 22749352
    17. NLRX1 interacts directly with RNA and suggestts a role for NLRX1 in recognition of intracellular viral RNA in antiviral immunity. PMID: 22386589
    18. the presence of NLRX1 is required for optimal chlamydial growth and reactive oxygen species production PMID: 20959452
    19. function of NOD-like receptors in the antiviral response [REVIEW] PMID: 18466630
    20. identification of NLRX1 as a check against mitochondrial antiviral responses--an intersection of three ancient cellular processes: NLR signalling, intracellular virus detection and the use of mitochondria as a platform for anti-pathogen signalling PMID: 18200010
    21. These results identify NLRX1 as a NLR that contributes to the link between reactive oxygen species generation at the mitochondria and innate immune responses. PMID: 18219313
    22. sequesters MAVS away from RIG-I and thereby prevents mitochondrial anti-viral immunity PMID: 18397740
    23. NLRX1 has a functional leader sequence and fully translocates to the mitochondrial matrix. PMID: 19692591

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  • 亚细胞定位：
    Mitochondrion outer membrane.
  • 蛋白家族：
    NLRP family
  • 组织特异性：
    Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level).
  • 数据库链接：

    HGNC: 29890

    OMIM: 611947

    KEGG: hsa:79671

    STRING: 9606.ENSP00000292199

    UniGene: Hs.524082