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NMNAT3 Antibody

  • 中文名称：
    NMNAT3兔多克隆抗体
  • 货号：
    CSB-PA839418LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: NMNAT3 antibody at 2µg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 29, 25, 19 kDa
      Observed band size: 29 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA839418LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA839418LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NMNAT3 Polyclonal antibody
  • Uniprot No.：
    Q96T66
  • 基因名：
    NMNAT3
  • 别名：
    NaMN adenylyltransferase 3 antibody; Nicotinamide mononucleotide adenylyltransferase 3 antibody; Nicotinamide nucleotide adenylyltransferase 3 antibody; Nicotinate-nucleotide adenylyltransferase 3 antibody; NMN adenylyltransferase 3 antibody; NMNA3_HUMAN antibody; NMNAT 3 antibody; Nmnat3 antibody; PNAT 3 antibody; PNAT-3 antibody; PNAT3 antibody; Pyridine nucleotide adenylyltransferase 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 protein (1-215AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NMNAT3 Antibody (CSB-PA839418LA01HU)，的标记方式是Non-conjugated。对于NMNAT3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA839418LB01HU NMNAT3 Antibody, HRP conjugated ELISA
    FITC CSB-PA839418LC01HU NMNAT3 Antibody, FITC conjugated
    Biotin CSB-PA839418LD01HU NMNAT3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.
  • 基因功能参考文献：
    1. NMNAT3 is absent in mitochondria in human cells, and, akin to plants and yeast, cytosolic NAD maintains the mitochondrial NAD pool. PMID: 24155910
    2. Red blood cells represent the first human cell type with a remarkable predominance of NMNAT3 over NMNAT1; NMNAT2 is absent. PMID: 20457531
    3. analysis of isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases PMID: 20388704
    4. NMNAT1 is a nuclear protein, whereas NMNAT2 and -3 are localized to the Golgi complex and the mitochondria PMID: 16118205
    5. NMN binds before ATP with the mitochondrial isozyme NMNAT3. Only NMNAT3 utilizes ITP efficiently in place of ATP, and NMNH conversion to NADH by NMNAT1 and NMNAT3 occurs at similar rates. PMID: 17402747

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Eukaryotic NMN adenylyltransferase family
  • 组织特异性：
    Expressed in lung and spleen with lower levels in placenta and kidney.
  • 数据库链接：

    HGNC: 20989

    OMIM: 608702

    KEGG: hsa:349565

    STRING: 9606.ENSP00000340523

    UniGene: Hs.208673