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NNT Antibody

  • 货号：
    CSB-PA015908GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q13423
  • 基因名：
    NNT
  • 别名：
    GCCD4 antibody; mitochondrial antibody; NAD(P) transhydrogenase antibody; NAD(P) transhydrogenase mitochondrial antibody; Nicotinamide nucleotide transhydrogenase antibody; NNT antibody; NNTM antibody; NNTM_HUMAN antibody; Pyridine nucleotide transhydrogenase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NNT
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.
  • 基因功能参考文献：
    1. Overexpression of nicotinamide nucleotide transhydrogenase (NNT) was associated with shorter overall and disease free survival in gastric cancer. Knockdown of NNT caused significantly NADPH reduction, induced high levels of Reactive Oxygen Species and significant cell apoptosis under oxidative stress conditions such as glucose deprival and anoikis. PMID: 30059901
    2. Findings suggest that NNT is essential to homeostasis of NADH and NADPH pools, anomalies of which affect HIF-1alpha- and HDAC1-dependent pathways, and hence retrograde response of mitochondria. PMID: 28478381
    3. Study describes the fi rst structural model of the human NNT. The 3D model identifies functional and structural H-NNT key motifs and gain essential insight into the structural and functional effect of deleterious amino acid substitutions causing glucocorticoid de fi ciency and LVNC cardiomyopathy, as well as rare homozygote amino acid variations. PMID: 27459240
    4. NNT should be sequenced in all primary adrenal insufficiencies for which the most frequent etiologies have been ruled out. As NNT is involved in oxidative stress, careful follow-up is needed to evaluate mineralocorticoid biosynthesis extent, and gonadal, heart and thyroid function. PMID: 27129361
    5. identified a 6.67 Mb homozygous region harboring the NNT gene in a Dutch patient presenting with familial glucocorticoid deficiency (FGD); a novel homozygous mutation (NM_012343.3: c.1259dupG) in NNT was revealed; reviewed the literature for all the reported NNT mutations and their clinical presentation PMID: 26548497
    6. This report of a novel NNT mutation, p.G200S, expands the phenotype of NNT mutations to include mineralocorticoid deficiency. It provides the first evidence that NNT mutations can cause oxidative stress and mitochondrial defects. PMID: 26070314
    7. Data suggest mutations in nicotinamide nucleotide transhydrogenase (NNT) as contributory to left ventricular noncompaction (LVNC). PMID: 26025024
    8. NNT mRNA expression is significantly higher in visceral fat of obese patients and correlates with body weight, BMI, % body fat, visceral and sc fat area, waist and hip circumference, and fasting plasma insulin. PMID: 23592659
    9. Results suggest that NNT may have a role in ROS detoxification in human adrenal glands. PMID: 22634753
    10. In the failing heart a partial loss of Nnt activity adversely impacts NADPH-dependent enzymes and the capacity to maintain membrane potential, thus contributing to a decline in bioenergetic capacity, redox regulation and antioxidant defense. PMID: 20388492
    11. the expression of the transhydrogenase gene in subsections of the human brain showed a distribution that apparently varied as a function of neuronal density PMID: 12223207

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  • 相关疾病：
    Glucocorticoid deficiency 4 with or without mineralocorticoid deficiency (GCCD4)
  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
  • 蛋白家族：
    AlaDH/PNT family; PNT beta subunit family
  • 组织特异性：
    Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues.
  • 数据库链接：

    HGNC: 7863

    OMIM: 607878

    KEGG: hsa:23530

    STRING: 9606.ENSP00000264663

    UniGene: Hs.482043