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NOC2L Antibody

  • 货号：
    CSB-PA008683
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y3T9
  • 基因名：
    NOC2L
  • 别名：
    NET15 antibody; NET7 antibody; NIR antibody; NOC2 like antibody; NOC2 like nucleolar associated transcriptional repressor antibody; NOC2-like protein antibody; NOC2L antibody; NOC2L nucleolar associated transcriptional repressor antibody; NOC2L_HUMAN antibody; Novel INHAT (inhibitor of histone acetyltransferase) repressor antibody; Novel INHAT repressor antibody; Nucleolar complex associated 2 homolog (S. cerevisiae) antibody; Nucleolar complex protein 2 homolog antibody; PPP1R112 antibody; Protein NOC2 homolog antibody; Protein phosphatase 1 regulatory subunit 12 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human NOC2L.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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靶点详情

  • 功能：
    Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
  • 基因功能参考文献：
    1. A transcriptional repressor NIR functions in the rRNA biogenesis of both the 40S and 60S subunits. PMID: 22363708
    2. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. PMID: 20959462
    3. Upon recruitment by p53, NIR represses transcription of both p53-dependent reporters and endogenous target genes PMID: 16322561
  • 亚细胞定位：
    Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.
  • 蛋白家族：
    NOC2 family
  • 数据库链接：

    HGNC: 24517

    OMIM: 610770

    KEGG: hsa:26155

    STRING: 9606.ENSP00000317992

    UniGene: Hs.405987