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NOXA1 Antibody

  • 货号：
    CSB-PA015963LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: NOXA1 antibody at 2 μg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 51, 52, 46 kDa
      Observed band size: 51 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA015963LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA015963LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA015963LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    The production of NOXA1 polyclonal antibody is through immunizing rabbits with the recombinant human NOXA1 (150-313AA). The resulting antibody occurs as an unconjugated IgG. It is reactive with human and mouse samples. Its purity is over 95% using protein G purified. This anti-NOXA1 antibody has been demonstrated to recognize the NOXA1 protein in ELISA, WB, IHC, and IF applications. Its target protein NOXA1 is the functional homolog of p67phox in vascular smooth muscle cells (VSMCs) that modulates redox signaling and VSMC phenotype.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NOXA1 Polyclonal antibody
  • Uniprot No.：
    Q86UR1
  • 基因名：
    NOXA1
  • 别名：
    Antigen NY CO 31 antibody; Antigen NY-CO-31 antibody; FLJ25475 antibody; Inhibitory NADPH oxidase activator 1 antibody; MGC131800 antibody; NADPH oxidase activator 1 antibody; NCF2 like protein antibody; NCF2-like protein antibody; NOX activator 1 antibody; NOXA 1 antibody; Noxa1 antibody; NOXA1_HUMAN antibody; NY CO 31 antibody; p51 nox antibody; p51-nox antibody; p51NOX antibody; P67phox like factor antibody; P67phox-like factor antibody; SDCCAG31 antibody; Serologically defined colon cancer antigen 31 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human NADPH oxidase activator 1 protein (150-313AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NOXA1 Antibody (CSB-PA015963LA01HU)，的标记方式是Non-conjugated。对于NOXA1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015963LB01HU NOXA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA015963LC01HU NOXA1 Antibody, FITC conjugated
    Biotin CSB-PA015963LD01HU NOXA1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
  • 基因功能参考文献：
    1. Data from pull-down assay between the Noxo1 and Noxa1 showed that the SH3 domains (Noxa1) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region. PMID: 28625920
    2. A NOXA1 peptide blocked NOXA1-Nox1 binding. The finding identifies a NOXA1-activating domain and an isoform-specific Nox1 inhibitor. PMID: 24187133
    3. Phosphorylation of Thr341 allows Noxo1 to sufficiently interact with Noxa1, an interaction that participates in Nox1 activation PMID: 23957209
    4. Noxa1 has quite different kinetic properties from p67(phox) and suggest that Noxa1 may function as a moderate activator of Nox2. PMID: 22244833
    5. Tks4 and Tks5 directly bind to NoxA1. The integrity of the N-terminal PRR of NoxA1 is essential for this direct interaction with the Tks proteins. PMID: 20609497
    6. The Nox1-dependent generation of reactive oxygen species is dependent on Src phosphorylation of NoxA1 and Tks4. Blockage of phosphorylation of NoxA1 and Tks4 decreases Nox1-dependent ROS generation and blocks SrcYF-induced invadopodia formation. PMID: 20943948
    7. The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented. PMID: 20454568
    8. these results demonstrate that phosphorylation of NoxA1 is a part of the feedback mechanism that functions through activation of Rac with a net outcome of negative modulation of Nox1 activity. PMID: 20230789
    9. NoxA1 is the functional homolog of p67phox in vascular smooth muscle cells (VSMC) that regulates redox signaling and VSMC phenotype. PMID: 20083677
    10. These studies demonstrate that, in reconstituted NOX1/NOXO1/NOXA1 systems, the NOXA1 SH3 domain is not required for function but, when present, can critically modulate the activity of the enzyme system. PMID: 17602954
    11. PKA-phosphorylated NoxA1 is a new binding partner of 14-3-3 protein; this forms the basis of a novel mechanism regulating the formation of ROS by Nox1 and, potentially, other NoxA1-regulated Nox family members PMID: 17913709
    12. Essential role of NOXA1 in generation of reacgtive oxygen species induced by oxidized low density lipoprotein in endothelial cells is reported. PMID: 18568954
    13. a novel, inhibitory function for Noxa1 in Duox1 regulation. PMID: 18606821

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  • 亚细胞定位：
    Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
  • 蛋白家族：
    NCF2/NOXA1 family
  • 组织特异性：
    Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
  • 数据库链接：

    HGNC: 10668

    OMIM: 611255

    KEGG: hsa:10811

    STRING: 9606.ENSP00000342848

    UniGene: Hs.495554