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NPAS1 Antibody

  • 货号：
    CSB-PA020147
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q99742
  • 基因名：
    NPAS1
  • 别名：
    NPAS1 antibody; BHLHE11 antibody; MOP5 antibody; PASD5 antibody; Neuronal PAS domain-containing protein 1 antibody; Neuronal PAS1 antibody; Basic-helix-loop-helix-PAS protein MOP5 antibody; Class E basic helix-loop-helix protein 11 antibody; bHLHe11 antibody; Member of PAS protein 5 antibody; PAS domain-containing protein 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Neuronal PAS1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH.
  • 基因功能参考文献：
    1. Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions. PMID: 28499489
    2. Here the s examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. PMID: 27782878
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 7894

    OMIM: 603346

    KEGG: hsa:4861

    STRING: 9606.ENSP00000405290

    UniGene: Hs.79564