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NPC2 Antibody

  • 货号：
    CSB-PA634688LA01DO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Dog NPC2 Polyclonal antibody
  • Uniprot No.：
    Q28895
  • 基因名：
  • 别名：
    NPC2 antibody; NPC intracellular cholesterol transporter 2 antibody; Epididymal secretory protein E1 antibody; cE1 antibody; Niemann Pick type C2 protein homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Dog
  • 免疫原：
    Recombinant Dog NPC intracellular cholesterol transporter 2 protein (22-149AA)
  • 免疫原种属：
    Dog
  • 标记方式：
    Non-conjugated

    本页面中的产品，NPC2 Antibody (CSB-PA634688LA01DO)，的标记方式是Non-conjugated。对于NPC2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA634688LB01DO NPC2 Antibody, HRP conjugated ELISA
    FITC CSB-PA634688LC01DO NPC2 Antibody, FITC conjugated
    Biotin CSB-PA634688LD01DO NPC2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
  • 亚细胞定位：
    Secreted. Endoplasmic reticulum. Lysosome.
  • 蛋白家族：
    NPC2 family
  • 组织特异性：
    Epididymis. High levels are found in the caput and corpus regions. Weaker levels in the distal cauda and in the efferent ducts.
  • 数据库链接：

    STRING: 9615.ENSCAFP00000024889

    UniGene: Cfa.3781