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NPTX2 Antibody

  • 货号：
    CSB-PA016030GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P47972
  • 基因名：
    NPTX2
  • 别名：
    apexin antibody; NARP antibody; neuronal activity-regulated pentaxin antibody; Neuronal pentraxin 2 antibody; Neuronal pentraxin II antibody; Neuronal pentraxin-2 antibody; NP 2 antibody; NP-II antibody; NP2 antibody; NPII antibody; NPTX2 antibody; NPTX2_HUMAN antibody; pentraxin II, neuronal antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NPTX2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.
  • 基因功能参考文献：
    1. Neuronal pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer's disease spectrum. This research may advance the current understanding of Alzheimer's disease etiopathogenesis, while expanding early diagnostic techniques through the use of novel pro-inflammatory biomarkers, such as NPTX2. PMID: 27444967
    2. NPTX2 in human cerebrospinal fluid is reduced in subjects with Alzheimer's disease and shows robust correlations with cognitive performance and hippocampal volume. PMID: 28440221
    3. Decreased NPTX2 expression in rectal adenocarcinomas is associated with improved response to neoadjuvant chemoradiation and improved prognosis. PMID: 27083956
    4. we show that NPTX2 is a marker of poor prognosis for neuroblastoma patients. PMID: 26294210
    5. NPTX2 is overexpressed specifically in ccRCC primary tumors. PMID: 24962026
    6. NPTX2 repressed NF-kappaB activity by inhibiting AKT through a p53-PTEN-dependent pathway, thus explaining the hypermethylation and downregulation of NPTX2 in NF-kappaB-activated high-risk glioblastomas. PMID: 24078801
    7. Promoter methylation of NPTX2 is associated with glioblastoma. PMID: 23624749
    8. Detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas PMID: 23360791
    9. The visual cortex of NARP-deficient transgenic mice is hyperexcitable and unable to express ocular dominance, although many aspects of visual function are unimpaired. PMID: 23889936
    10. This study showed that the NPTX2 protein is down-regulated in human primary pancreatic cancers and in pancreatic cancer cell lines. PMID: 22806544
    11. This study demonistrated that childhood-onset mood disorders and suicide attempt association between HOMER1 rs2290639 and between NPTX2 markers rs705315 and rs1681248. PMID: 22460132
    12. Demonstrate for the first time that NARP mutation significantly enhances apoptotic death as a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca(2+), and lipid stress. PMID: 21812817
    13. Data indicate that the aberrantly methylated NPTX2 gene may help to distinguish between chronic pancreatitis and pancreatic cancer with conventional diagnostic tools and could become a valuable diagnostic marker. PMID: 21778928
    14. NPTX2, as a tumor-suppressor, plays an anti-tumor effect on pancreatic cancer and its low expression, due to promoter hypermethylation, may play a role in the tumorigenesis of pancreatic cancer. PMID: 21161403
    15. study tested for the association of four SNPs of NPTX2 & haplotypes consisting of the SNPs with autism, between autistic patients & controls in a Japanese population; no significant difference was observed in allele, genotype or haplotype frequencies PMID: 17408830
    16. pancreatic cancer cytology samples had statistically significant higher levels of NPTX2 methylation compared with benign diseases PMID: 17895837
    17. Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. PMID: 17987278
    18. Homoplasmic cybrids harboring the 8993T-->G NARP mutation were also protected from death (75% vs 15% survival at 72 hours) by the supplemented medium and their ATP content was similar to controls PMID: 19667215

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.
  • 数据库链接：

    HGNC: 7953

    OMIM: 600750

    KEGG: hsa:4885

    STRING: 9606.ENSP00000265634

    UniGene: Hs.3281