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NR2E1 Antibody

  • 货号：
    CSB-PA820920ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: NR2E1antibody at 3.2μg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 43, 47 kDa
      Observed band size: 43 kDa
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA820920ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA820920ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NR2E1 Polyclonal antibody
  • Uniprot No.：
    Q9Y466
  • 基因名：
    NR2E1
  • 别名：
    hTll antibody; NR2E1 / Tailless antibody; nr2e1 antibody; NR2E1_HUMAN antibody; Nuclear receptor subfamily 2 group E member 1 antibody; Nuclear receptor TLX antibody; Orphan nuclear receptor NR2E1 antibody; Protein tailless homolog antibody; Tailless homolog antibody; Tll antibody; TLX antibody; XTLL antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Nuclear receptor subfamily 2 group E member 1 protein (106-385AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acid receptor (RAR) regulation in retinal cells.
  • 基因功能参考文献：
    1. ASK1 phosphorylated and stabilized TLX, which led induction of HIF-1alpha, and its downstream VEGF-A in an Akt dependent manner. PMID: 27890558
    2. TLX and miR-219 have an important role in both normal neurodevelopment and in schizophrenia patient iPSC-derived NSCs. TLX has a role in regulating microRNA processing, independent of its well-characterized role in transcriptional regulation. PMID: 26965827
    3. TLX downregulation induces TET3 expression and inhibits glioblastoma tumorigenesis and self-renewal in glioblastoma stem cells. PMID: 26838672
    4. TLX has a role in regulating growth and invasion in ERalpha-negative breast cancer cells PMID: 26280373
    5. TLX biological role in mental illness and gliomagenesis PMID: 26554934
    6. Increased NR2E1 level may be closely associated with inflammation and disorder of lipid and glucose metabolism in diabetic patients. PMID: 25813674
    7. These results suggest that let-7b, by forming a negative feedback loop with TLX, provides a novel model to regulate the proliferation and differentiation of retinal progenitors in vitro PMID: 25327364
    8. NR2E1 regulates CBX7 and restrains senescence in neural stem cells. PMID: 25328137
    9. TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes PMID: 25557355
    10. The effect of TLX on the proliferative, invasive and migratory properties of IMR-32 cells attributed to the recruitment of TLX to both MMP-2 and Oct-4 gene promoters, which resulted in the respective gene activation. PMID: 25356871
    11. TLX is involved in interleukin (IL)-1beta-induced changes in adult hippocampal neurogenesis. PMID: 23510989
    12. TLX/NR2E1 and related NRs such as PNR and COUPTFs can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates TLX-mediated repression of the RARb2 gene. PMID: 23975195
    13. No mutations in the NR2E1 gene were found in aniridia patients. PMID: 23213277
    14. Enriched expression of TLX in higher-grade human gliomas is observed. PMID: 23028043
    15. BCL11A is a novel TLX coregulator that might be involved in TLX-dependent gene regulation in the brain. PMID: 22675500
    16. Cerebrum and olfactory bulb hypoplasia, hallmarks of the Nr2e1-null mice phenotype, were not fully corrected in animals harboring one functional copy of human NR2E1. PMID: 22290436
    17. Transgenic TLX acts as an essential regulator that ensures the proliferative ability of postnatal neural stem cells by controlling their activation through genetic interaction with p53 and other signaling pathways. PMID: 21957244
    18. Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia. PMID: 21135096
    19. Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression. PMID: 21368052
    20. Increased TLX expression was observed in a number of glioma cells and glioma stem cells, and correlated with poor survival of patients with gliomas. PMID: 20814749
    21. nuclear receptor tailless transcripts are overexpressed in human primary glioblastomas in which Tlx expression is restricted to a subpopulation of nestin-positive perivascular tumor cells PMID: 20360385
    22. compared sequence from human, mouse, and the puffer fish Fugu rubripes PMID: 12079282
    23. Transgenic human NR2E1 was sufficient to fix structural brain & eye abnormalities & hyperaggressiveness in mice deleted for mouse Nr2e1. NR2E1 protein & regulatory sequences are comparable between these species. PMID: 16000615
    24. Strong purifying selection, low genetic diversity, 21 novel polymorphisms and five common haplotypes at were detected at NR2E1; protein-coding changes do not contribute to cortical and behavioral abnormalities, but regulatory mutations may play a role. PMID: 17054721
    25. we cannot exclude the possibility that deletions at NR2E1 may underlie MMEP, given that sequencing is unable to distinguish between homozygosity across loci versus large deletions PMID: 17655765
    26. TLX recruits histone deacetylases to repress transcription of p21(CIP1/WAF1) and pten and regulate neural stem cell proliferation PMID: 17873065
    27. Genetic variation at NR2E1 may be associated with susceptibility to brain-behavior disorders. PMID: 18205168
    28. LSD1 is a histone demethylase that is the prime corepressor for TLX PMID: 18391013
    29. TLX is an inducer of SIRT1 and may contribute to neurogenesis both as a transactivator and as a repressor. PMID: 19555662

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR2 subfamily
  • 组织特异性：
    Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.
  • 数据库链接：

    HGNC: 7973

    OMIM: 603849

    KEGG: hsa:7101

    STRING: 9606.ENSP00000357982

    UniGene: Hs.157688