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NRDC Antibody

  • 货号：
    CSB-PA016075LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, PC-3 whole cell lysate
      All lanes: NRDC antibody at 3.73µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 132, 140 kDa
      Observed band size: 132 kDa
    • Immunofluorescence staining of Hela cells with CSB-PA016075LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NRDC Polyclonal antibody
  • Uniprot No.：
    O43847
  • 基因名：
    NRDC
  • 别名：
    NRDC antibody; NRD1 antibody; Nardilysin antibody; EC 3.4.24.61 antibody; N-arginine dibasic convertase antibody; NRD convertase antibody; NRD-C antibody; Nardilysin convertase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nardilysin protein (32-113AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NRDC Antibody (CSB-PA016075LA01HU)，的标记方式是Non-conjugated。对于NRDC Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA016075LB01HU NRDC Antibody, HRP conjugated ELISA
    FITC CSB-PA016075LC01HU NRDC Antibody, FITC conjugated
    Biotin CSB-PA016075LD01HU NRDC Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
  • 基因功能参考文献：
    1. NRDC expression was reduced in infarcted regions in autopsy samples from acute myocardial ischemia patients. PMID: 28747015
    2. Gene expression level of NRD1 is significantly higher in AD patients when compared to normal controls. PMID: 26943237
    3. MRNA expression of NRD1 was upregulated in 56% of ESCC tissue samples. PMID: 24168165
    4. This study demonistrated that alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism. PMID: 23219461
    5. possible roles of nardilysin in Alzheimer disease, Down syndrome, schizophrenia, mood disorders, alcohol abuse, heroin addiction and cancer; show that nardilysin is a Janus-faced enzyme with regard to brain pathology-- probably neuropathogenic in some diseases, but neuroprotective in others [review] PMID: 23604405
    6. SH-SY5Y cells, stably transfected with green fluorescent protein-tagged-p42(IP4) show enhanced NRD protein expression already at an earlier time point after retinoic acid stimulation. PMID: 21801775
    7. NRD1 interacts with p53 mutant R273H PMID: 22653443
    8. These results demonstrate that gastric cancer cell growth is maintained by autonomous TNF-alpha-NF-kappaB and IL-6-STAT3 signalling, and that NRDc and ADAM proteases turn on these signalling cascades by stimulating ectodomain shedding of TNF-alpha. PMID: 22351606
    9. Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. PMID: 22294699
    10. Several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample for KIAA0040, NRD1 and THSD7B, respectively. PMID: 21703634
    11. Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-alpha1 (ADAP1). PMID: 21972134
    12. mediates antigen processing that generates cytotoxic T cell epitopes PMID: 21151101
    13. nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF) PMID: 12095415
    14. Nardilysin has an essential role in HB-EGF ectodomain shedding, which is regulated by the modulation of sheddase activity PMID: 16923819
    15. We found high staining intensity in the hypothalamus, neocortex and brain stem nuclei. The cellular localization is almost exclusively confined to neurons. In pre- and perinatal human brain cortex, most neurons express the enzyme. PMID: 17442499
    16. These results indicate the involvement of NRDc in ectodomain shedding of TNF-alpha. PMID: 18355445
    17. Nardilysin convertase regulates the function of the maxi-K channel isoform mK44 in human myometrium. PMID: 19118164
    18. N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor (HB-EGF) that modulates HB-EGF-induced cell migration. PMID: 11432822
    19. The acidic stretch of nardilysin, expressed as a fusion protein with glutathione S-transferase and compared to the native enzyme with respect to spermine binding, functions as an autonomous domain. PMID: 11478915

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  • 蛋白家族：
    Peptidase M16 family
  • 组织特异性：
    Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.
  • 数据库链接：

    HGNC: 7995

    OMIM: 602651

    KEGG: hsa:4898

    STRING: 9606.ENSP00000346890

    UniGene: Hs.584782