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NREP Antibody

  • 货号：
    CSB-PA070288
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q16612
  • 基因名：
    NREP
  • 别名：
    3.1 gene antibody; C5orf13 antibody; Chromosome 5 open reading frame 13 antibody; D4S114 antibody; Neuronal protein 3.1 antibody; Neuronal regeneration related protein antibody; Neuronal regeneration related protein homolog (rat) antibody; Neuronal regeneration related protein homolog antibody; NP311_HUMAN antibody; NREP antibody; P311 antibody; PRO1873 antibody; Protein p311 antibody; PTZ17 antibody; SEZ17 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human P311.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration. May also have functions in cellular differentiation. Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation.
  • 基因功能参考文献：
    1. P311 is a novel TGFbeta1/Smad signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing. PMID: 27906099
    2. P311 could accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cell through RhoA and Rac1 activation. PMID: 27927130
    3. These studies demonstrate that P311 is required for the production of normal cutaneous scars PMID: 27939132
    4. P311 plays a key role in renal fibrosis via TGFbeta1/Smad signaling, which could be a novel target for the management of renal fibrosis. PMID: 26616407
    5. P311 may promote the migration of ESCs both in micewith superficial partial-thickness burns and in an injured cell model in vitro, and it may play an important role in wound healing. PMID: 22967977
    6. Protein HYI may closely bind with protein P311 by an alpha helix in hypertrophic scar fibroblasts. PMID: 22490543
    7. P311 and ITGB4BP expression was elevated in non-small cell lung cancer, possibly indicative of a new signaling pathway. PMID: 21029697
    8. P311 may be involved in the pathogenesis of hypertrophic scar via induction of a myofibrobla PMID: 20404911
    9. role for P311 in inducing TGF-beta1-independent myofibroblast transformation PMID: 12417574
    10. These results suggest a role for levels of P311 in regulating glioma motility and invasion through the reorganization of actin cytoskeleton at the cell periphery. PMID: 16229809
    11. P311 expression is tightly regulated during the critical periods of alveolar formation, and that under pathologic conditions, its relative absence may contribute to failure of alveolar regeneration and lead to the development of human emphysema. PMID: 16484684

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed in lung (at protein level).
  • 数据库链接：

    HGNC: 16834

    OMIM: 607332

    KEGG: hsa:9315

    UniGene: Hs.36053